Hi Kaichos Man,
You misunderstood Drosphilla's reply. Your argument is that neutral mutations, since they produce no phenotypic change, cannot be selected. We all agree with you, including Drosophilla. He was talking about mutations that
*do* produce phenotypic change and that
*are* acted upon by natural selection, explaining that small changes gradually accumulate into larger changes. This includes the gradual accumulation of neutral mutations where at some point one additional mutation does cause phenotypic change.
As has been explained, you seem to be misunderstanding Kimura as saying that so few mutations produce phenotypic change that they cannot be a factor in evolution, and that's not what Kimura said. The Kimura quote you're so fond of talks only of change at the molecular level, not at the phenotypic level.
Kaichos Man writes:
Of course, that can be caused by a single nucleotide switching an existing gene on or off, but that's not creating new information, it's merely modifying existing information.
Modifying existing information creates new information. If we label the original information "a", and we modify it to become "b", then "b" is new information. Depending upon the specific circumstances "b" might represent more or less information than "a", but it is definitely new and different information that did not exist before.
--Percy
Edited by Percy, : Add clarification to first paragraph.