I would certainly enjoy you being in my craps game! This does not relate to the discussion, IMHO, because your die do not have the same number of sides and therefore are not equiprobable. There are exactly 4 bases that form the codons in DNA. Any of these bases can mutate, so is one base more probable to mutate than another? I don't think so and I would have to see the math and what it based on before I would be convinced otherwise.
OK, good I'm not going crazy. This basically is a respsonse to your dismissal of
Message 134. It seems to me that certain phenemenon can 'load the dice', or to quote one of the abstracts:
quote:
Mutation frequencies vary significantly along nucleotide sequences such that mutations often concentrate at certain positions called hotspots.
The term 'mutation frequencies vary' seems to me to be saying that mutation probabilities aren't equiprobable.
- Have I interpreted the abstract correctly?
- Do you agree with the abstract?
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At first I didn't understand what you meant when you said:
I don't see how. We have PhDs that do this kind of math...I would see no cases where probabilities cannot be calculated when probabilities are known to occur.
in response to my question "Can't the probability of something be impossible to calculate but be simply more likely to occur than something else?" I understand why I'm confused now. It lies in your earlier statement:
Now is there anyone you know who can sit down and calculate the probabilities of what will mutate the next time an organism reproduces? No. Therein lies the answer. They ARE random.
You seemed to be implying that since someone cannot calculate a probability it must be random. Am I right? The problem of course, is that you then say that we have eggheads that can do the math, and that (as far as you know) probabilities are calcuable if we know probabilities occur.
So either you made a slip up, which is fine, I understand, no problem. Or there isn't a probability involved in mutations, which seems odd to me. Perhaps there is another option I haven't perceived?
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This message has been edited by Modulous, 05-06-2005 07:37 PM
This message has been edited by Modulous, 05-06-2005 07:39 PM