What difference does it make what is the sender? What difference does it make what is the receiver? What difference does it make what the message is?
Er, it's your definition, if you don't know what these things are with respect to biological systems, how can we apply it to them?
Information as we know it comes from a mind.
Bullshit. There's information all around us that doesn't come from minds. Look out the window, up at the sky - do you really think you receive no information about the weather? No information about the time of day?