Hi Shadow,
I think you maybe meant something like this:
PRATT: All mutations are random with respect to fitness.
Response: Mutations in the form of insertions in the CRISPR loci of DNA are not random with respect to fitness.
But the response won't mean anything to almost everyone. This thread is seeking short and effective responses to PRATTs.
More importantly, most scientists would inherently averse to absolute statements like "All mutations are random with respect to fitness." Years of research counsels, shall we say, more tentative expressions.
So if you go by what a scientist trying to be brief would be more likely to say, "Mutations are random with respect to fitness," then this isn't really a PRATT because the vast majority of mutations must be random with respect to fitness by the very manner of their creation: microbiological mistakes during copying or other DNA-related processes.
--Percy