No one seems interested that the best microbiology has been able to accomplish is 1+1=2.
Ok, 1 +1 =2. Then we're at 2, and 2 + 1 = 3, then we're at 3, and 3 + 1 = 4. Now we're at 4, and 4 + 1 = 5. 5 + 1 = 6. 6 + 1 = 7. 7 + 1 = 8. 8 + 1 = 9. 9 + 1 = 10.
Lots of little changes add up to a big change. What you need to do, to allow micro but deny macro, is come up with some mechanism that stops little changes from accumulating.