"....Change is built into the genome, but it can only vary the traits of the particular Species that are programmed into its genome, it can never produce something that is not already genetically available to that Species. Oodles of time isn't going to make one Species into another if the genetic program for all the characteristics of a given Species is limited to what is already packed into its genome. This is macroevolution's ultimate downfall...."
This is an oft repeated opinion offered by creationists. There are several problems with it, in addition to the lack of documentation for the opinion. One is this false dichotomy between "micro" and "macro" evolution. There is no such divide. Another is the fact that the tracks of evolutionary change are left as clearly as footprints in fresh snow via DNA. Homo sapiens and both Pan troglodytes and Pan paniscus share 99% of their DNA. This makes the fact of their morphological similarities more than coincidence.
Anyone who has raised identical twins has observed the dramatic effects of mutation in just one generation. Their twins may have started out with identical DNA, having come from the same zygote; however, in just nine months in utero the mutations have yielded differences noticeable to all but a casual observer.