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Author Topic:   Explaining the pro-Evolution position
Genomicus
Member (Idle past 167 days)
Posts: 852
Joined: 02-15-2012


Message 12 of 393 (792248)
10-07-2016 1:57 PM
Reply to: Message 10 by Kleinman
10-07-2016 1:51 PM


You are half right ringo and to start the explanation why you are only half right, answer the same question I pose for Tangle. Why does combination therapy work for the treatment of HIV?

I'm going to take a gander and guess that you've recently read Behe's The Edge of Evolution. Right?


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Genomicus
Member (Idle past 167 days)
Posts: 852
Joined: 02-15-2012


Message 14 of 393 (792250)
10-07-2016 2:08 PM
Reply to: Message 13 by Kleinman
10-07-2016 2:04 PM


Why does combination therapy work for the treatment of HIV?

Multi-valent drug approaches to HIV are more effective because there is a lower probability of the HIV population hitting on the right mutations to counter both drugs simultaneously.

Next.


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Genomicus
Member (Idle past 167 days)
Posts: 852
Joined: 02-15-2012


Message 41 of 393 (792297)
10-07-2016 7:30 PM
Reply to: Message 15 by Kleinman
10-07-2016 2:17 PM


Good, you are on the right track for understanding how random mutation and natural selection (rmns from here on) works.

I am quite familiar with population genetics and molecular evolution, but sure, yeah -- thanks for your laudatory comments I guess?

So consider the simpler case when HIV evolves very rapidly to single drug therapy. How do compute this probability?

We'd need to know population size, fitness of wildtype viruses compared to drug-resistant mutants, mutation rate, no. of copies of mutant phenotype in the population, etc., to estimate probability of fixation of the drug-resistant mutation.

But get to the point. You don't need to walk me through pop genetics.


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