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Author Topic:   Random DNA Sequences Contain Information
caffeine
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Posts: 1800
From: Prague, Czech Republic
Joined: 10-22-2008


Message 6 of 18 (815606)
07-21-2017 3:16 PM
Reply to: Message 5 by AnswersInGenitals
07-20-2017 5:21 PM


Re: If You Can Raed Tihs, You Msut Be Raelly Smrat
These results still seem surprising to me. Robustness through redundancy is the reason people always say most mutations are neutral with respect to fitness. Due to the redundancies in the genetic code, a lot of mutations don't have any phenotypic effect.

In this case they're not just claiming their random variants were harmless due to inbuilt redundancies - a quarter of them were actually fitter than the originals. That's surprising to me.


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 Message 5 by AnswersInGenitals, posted 07-20-2017 5:21 PM AnswersInGenitals has not yet responded

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caffeine
Member
Posts: 1800
From: Prague, Czech Republic
Joined: 10-22-2008


Message 8 of 18 (815608)
07-21-2017 3:25 PM
Reply to: Message 7 by Taq
07-21-2017 3:19 PM


Re: If You Can Raed Tihs, You Msut Be Raelly Smrat
There are no "originals" in this experiment since they are random 150 base pair DNA segments bookended by a promoter and terminator.

I thought these were inserted into bacterial genomes and then the resulting bacteria competed against wild-type individuals. Did I misunderstand the abstract?


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 Message 7 by Taq, posted 07-21-2017 3:19 PM Taq has responded

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 Message 9 by Taq, posted 07-21-2017 3:32 PM caffeine has acknowledged this reply
 Message 11 by Dr Jack, posted 07-22-2017 10:00 AM caffeine has acknowledged this reply

  
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