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Member (Idle past 1635 days) Posts: 104 From: Ottawa, ON, Canada Joined: |
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Author | Topic: NvC-1: What is the premise of Naturalism in Biology? | |||||||||||||||||||||||
Kleinman Member (Idle past 625 days) Posts: 2142 From: United States Joined: |
PaulK writes:
Information like beauty is in the eye of the beholder.
While these arguments as I have presented them fall short of proof they still represent a very good reason to think that mutations can add information. Unless they can be overcome it is not at all reasonable to insist that mutations cannot add information.
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Kleinman Member (Idle past 625 days) Posts: 2142 From: United States Joined: |
Kleinman writes:
The problem with your argument is that it is vague. You make the statement, "there are two arguments which make a case that mutation [sic] can add information"? What do you mean by "add information" and how do you measure this? Do all mutations add information?
Information like beauty is in the eye of the beholder.PaulK writes: An assertion that does more to undermine Richard Wang’s arguments than mine.
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Kleinman Member (Idle past 625 days) Posts: 2142 From: United States Joined: |
Kleinman writes:
I'm not Richard. So, let's see what your pre-conceived idea of what genetic information is.
Information like beauty is in the eye of the beholder.AZPaul3 writes: In other words your definition can be whatever you need it to be to fit your pre-conceived conclusion. Such a scientist you are, Richard. AZPaul3 writes:
Do you mean nail it down hard such as you nailed it down hard on the number of replications necessary for a beneficial mutation to occur in the Kishony experiment? You hammered that down to between 1 and infinity. Such a scientist you are.
Nail it down hard.AZPaul3 writes:
What information are you seeing there? And what is the difference in the information from one sequence of nucleobases to another?
In talking about genetic mutations, information is defined as the sequence of nucleobases present in any specific nucleic acid portion.AZPaul3 writes:
Again, I'm not Richard. Your definitions are vague. For example, you say "this sequence of bases, in this specific order, is the information contained in this DNA segment". Are you saying that any sequences of bases has information in it? If so, that's like saying any sequence of letters can make up words, sentences, paragraphs, chapters,... You haven't defined information as it pertains to genetics and how you measure it. So, what information is your eye beholding in these genetic sequences? I think you need a rosetta stone to decipher the information in your genetic hieroglyphics.
By convention, a human construct, the bases are labeled A, C, T, G in a DNA strand. As a starting initial sequence a short strand of DNA (double helix) may be represented as: ATCCATAGCAAAGCGCTTGAGATCCGGTTATACGGCTTGCGATGGGATATCCAGAGCTTAACCGCGTA As our example, this sequence of bases, in this specific order, is the information contained in this DNA segment. By convention, any change in this sequence of bases, by whatever means, is called a mutation of the starting initial sequence. *ANY* change to the initial sequence of bases in a DNA segment is a mutation. As a result, *ANY* mutation is a change in information. Richard, do you agree with these definitions? If not, where/why would you differ?
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Kleinman Member (Idle past 625 days) Posts: 2142 From: United States Joined: |
Kleinman writes:
Even Taq was able to hammer that one better than you when he calculated 3e9 replications for each beneficial mutation. How does that serve you?
You hammered that down to between 1 and infinity. Such a scientist you are.AZPaul3 writes: And I was right, despite your self-serving bogus mathematics.Kleinman writes:
How much information in the sequence? Is that another one with between 1 and infinity? Such a scientist you are. And we marvel at your mathematical skills.
What information are you seeing there?
AZPaul3 writes: Dense as a stump. The information is the sequence of the nucleobases. If you can't understand what that means then take a semester of beginning genetics.Kleinman writes:
So if the sequence is twice as long, it has between 2 and 2*infinity amount of information? Such a scientist you are.
And what is the difference in the information from one sequence of nucleobases to another?AZPaul3 writes: The difference in the sequence *is* the difference in the information. You got a real strong handle on this don't ya.Kleinman writes:
So, how much does a mutation change the information in a sequence? Is that between 1 and infinity as well? Such a scientist you are.
Are you saying that any sequences of bases has information in it?AZPaul3 writes: If you understood how DNA relates to genetics you would know the answer to that question. Right now we're not relating the information to the chemical operations. We're only establishing that the sequence is the information and that changes to the sequence is mutation.Kleinman writes:
Well, thank you for nailing down for us that genetic information is simply a sequence and it has a value of 1 to infinity. Such a scientist you are.
Again, I'm not Richard.AZPaul3 writes: Again my apologies. This message isn't for you. I'll wait for Dr. Wang to respond.
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Kleinman Member (Idle past 625 days) Posts: 2142 From: United States Joined: |
If you don't mind, let me give the Pauls some help. If you correlate biological fitness with information, here's an experimental example of where a mutation increases biological information.
https://www.youtube.com/watch?v=Irnc6w_Gsas What you are observing is a Markov Chain which is a second law of thermodynamics process. And of course, information and entropy are related.
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Kleinman Member (Idle past 625 days) Posts: 2142 From: United States Joined: |
RLW writes:
Why? You don't understand how this changes the mathematics of DNA evolution. I've given you a link which introduces you to Markov models of DNA evolution: So, I suggest we change a topic, for example, mutations,Taq writes: Ok. Let's first look at transversion and transition mutations.Models of DNA evolution - Wikipedia The Jukes-Cantor model assumes the mutation rate for transversions and transitions are equal. The Kimura model takes into account that transversions and transitions have different mutation rates. But there is a fundamental assumption that is made when deriving these models that makes these models incorrect. You should study these models and try to figure out why. Then you might actually understand something about DNA evolution and the mathematics which governs this process.
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Kleinman Member (Idle past 625 days) Posts: 2142 From: United States Joined: |
Kleinman writes:
You don't even have a horse in this race. You should stick with posting in the "Coffee House" and "Faith and Belief" forums. You certainly don't have the mathematical skills to be posting in the "Is it Science" and "Biological Evolution" forums. If you did have any mathematical skills, you could explain the Jukes-Cantor and Kimura models of DNA evolution and the differences between those two models. And then you could explain how to apply these models to the Kishony Mega-plate experiment. But you don't have those skills.
Why? You don't understand how this changes the mathematics of DNA evolution.Taq writes: You are wearing out your hobby horse.
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Kleinman Member (Idle past 625 days) Posts: 2142 From: United States Joined: |
Kleinman writes:
If you think your understanding of exons and introns can explain the mathematics of DNA evolution, do it. And if you think your understanding of exons and introns can explain mutations and how they relate to genetic information, do it. You certainly don't have the mathematical skills to be posting in the "Is it Science" and "Biological Evolution" forumsTaq writes: So says the person who didn't know what exons and introns are. If you don't think my posts are worthy of comment then don't respond to them. You had a good start with your posts when you calculated 3e9 replication for a beneficial mutation to occur for the Kishony Mega-plate experiment but then you stopped attempting to understand. Instead, you bring up exons and introns which really have nothing to do with DNA evolution and genetic transformation or recombination which is related to genetic transformation (and therefore phenotype) but has little effect on DNA evolution (but you don't know why). But then you stop when I ask you to explain the mathematics of random recombination. Try studying a little harder and learn and understand the mathematics of genetic transformation and what genetic information is all about. You really don't understand this subject as well as you claim you do.
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Kleinman Member (Idle past 625 days) Posts: 2142 From: United States Joined: |
Kleinman writes:
If you understood the subject of population genetics, you would understand how mutations and genetic information is related to this subject. Go back to [MSG=362] and [MSG=363] and see that I am right on topic. Instead, you resort to name-calling. I'm presenting empirical and mathematical evidence. You have a superficial understanding of the empirical evidence. You showed that when you computed that it would take 3e9 replications for each beneficial mutation in the Kishony Mega-plate experiment. How does this relate to genetic information? But instead, you are either unwilling or unable to go further. Why won't you attempt to understand this subject?
If you think your understanding of exons and introns can explain the mathematics of DNA evolution, do it. And if you think your understanding of exons and introns can explain mutations and how they relate to genetic information, do it.Taq writes: In case you didn't notice, this isn't a topic on the math of population genetics. One of the signs of a crackpot is that they bring up the same stale topic no matter what the thread is about.
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Kleinman Member (Idle past 625 days) Posts: 2142 From: United States Joined: |
Kleinman writes:
The empirical evidence starts with the Kishony and Lenski experiments. And you started scratching the surface on the math with your calculation of 3e9 replication for each evolutionary step in the Kishony experiment. I already know how to do the math. If you can't do the math and you find that insulting, learn how to do the math.
I'm presenting empirical and mathematical evidence.Taq writes: Evidence of what? What point are you trying to make? Do you have something other than insulting people while demanding that they do math problems?Kleinman writes:
Genetic information has to be measured in the context of the environment. So, consider the Kishony experiment. What mutations give increased information (fitness) for that environment? And what is the rate of accumulation of that information? That is your Markov chain calculation. And if you know how to do that calculation, you will understand how DNA evolution works and how it relates to genetic information. Didn't they teach you any of this in your biology class?
How does this relate to genetic information?
Taq writes: You tell us. Get to the point.
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Kleinman Member (Idle past 625 days) Posts: 2142 From: United States Joined: |
Kleinman writes:
I'll say it again and as many times as necessary for you to get it. DNA evolution is a Markov Chain process. From the way you are posting, it appears you have no idea what a Markov Chain process is. Here's a simple introductory video to learn how you do a Markov Chain calculation. This is part 1, it wouldn't hurt for you to watch all three parts. The empirical evidence starts with the Kishony and Lenski experiments.Taq writes: Ok. Keep going.Kleinman writes: Genetic information has to be measured in the context of the environment. So, consider the Kishony experiment. What mutations give increased information (fitness) for that environment? And what is the rate of accumulation of that information? That is your Markov chain calculation. And if you know how to do that calculation, you will understand how DNA evolution works and how it relates to genetic information.Taq writes: Then how does DNA evolution work and how does it relate to genetic information? Spit it out.https://www.youtube.com/watch?v=uvYTGEZQTEs
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Kleinman Member (Idle past 625 days) Posts: 2142 From: United States Joined: |
Kleinman writes:
To understand this, you first need to recognize that DNA evolution is a stochastic process (mutations occur randomly). Then, from this link: DNA evolution is a Markov Chain process.Taq writes: So how does that relate to information in genetics, and how does it relate to the role of naturalism in biology?Entropy rate - Wikipedia "In the mathematical theory of probability, the entropy rate or source information rate of a stochastic process is, informally, the time density of the average information in a stochastic process. Since a stochastic process defined by a Markov chain that is irreducible, aperiodic and positive recurrent has a stationary distribution, the entropy rate is independent of the initial distribution."Then, further down in this link, they show you how to compute this value for a Markov chain process: "For example, for such a Markov chain... (equations from link which don't format correctly here) is the asymptotic distribution of the chain. A simple consequence of this definition is that an i.i.d. stochastic process has an entropy rate that is the same as the entropy of any individual member of the process." The problem with trying to apply this equation directly to actual evolutionary examples such as the Kishony and Lenski experiments (and really all examples of evolution) is that these real DNA evolutionary processes are not stationary, that is they don't go to equilibrium. At equilibrium, the distribution of bases at any site in a population no longer changes. If you look at the Markov DNA evolution models from this link:Models of DNA evolution - Wikipedia You will find that these models (e.g. Jukes-Cantor, Kimura) are stationary models. That is, after some period of time, the frequencies of A, C, G, and T all go to 0.25. That is 1/4 of the population will have an A base at the given site, 1/4 of the population will have a C base at the given site and likewise for the G and T bases. The Kishony and Lenski experiments get nowhere close to that distribution. What that means is that the transition matrix they are using is incorrect and that real DNA evolutionary process gets nowhere close to equilibrium. If you want to learn how information and entropy are related, get a copy of the following text:Amazon.com Andrews has a chapter in this book where he derives Shannon's information equation from the Boltzmann's entropy formula. The way this relates to naturalism is to do your naturalism correctly. Learn how to correlate your math to reality, not to some vision you have. Darwin recognized what the two fundamental phenomena of evolution were, what he called the struggle for existence (and what we call competition), and adaptation (what we call DNA evolution). What Darwin didn't do is quantify these phenomena. As a naturalist, you should want to quantify these concepts correctly because then you can correctly predict things such as the evolution of drug-resistance or the failure of cancer treatments.
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Kleinman Member (Idle past 625 days) Posts: 2142 From: United States Joined: |
Kleinman writes:
Yep, the correct way to do the naturalism of DNA evolution. You should learn how to do it.
The way this relates to naturalism is to do your naturalism correctly.Taq writes: That was assumed from the very start of this thread. Is that all you have as it relates to the topic?
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Kleinman Member (Idle past 625 days) Posts: 2142 From: United States Joined: |
Kleinman writes:
Yes, but only if you do the mathematics correctly and the link you posted, they don't do the mathematics correctly. And you don't know why.
You should learn how to do it.Taq writes: So you would agree that biology can be understood in terms of naturalism?
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Kleinman Member (Idle past 625 days) Posts: 2142 From: United States Joined: |
Richard L. Wang writes:
Actually, Darwinian evolution is qualitatively correct. It's when you quantitate his theory that you run into problems.
As I wrote in RLW(Message 429), this shows again that you have lost the debate on whether Darwinian-Naturalism is pseudoscience.
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