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Author | Topic: What have we accomplished? | |||||||||||||||||||||||||||||||||
Kleinman Member (Idle past 633 days) Posts: 2142 From: United States Joined: |
PaulK writes:
The only thing you have proven is that you are a direct descendant from bananas. And I suggest you submit your work for publication, in Mad magazine.
For the benefit of anyone actually interested in understanding the model. I’ll answer. But thanks for proving your incompetence.Kleinman writes:
What a surprise, a fish-to-mammals aficionado thinks that DNA evolution is an equilibrium process. Just one more reason that shows you are a mathematically incompetent bungler.
I've posted the links multiple times which explain the Jukes-Cantor model. Here's the one which explains how you derive the Jukes-Cantor model and that for a mutation rate of e-8, it takes 50,000,000 generations for just a single base in a single genePaulK writes: Wrong. It takes 50,000,000 generations to get to the equilibrium state, which is not a single mutations. To quote from the article:Kleinman writes:
Are you sure you want to do this PaulK. I mean you are making one mathematical blunder after another. The Juke-Cantor describes DNA evolution at just a single site, not to all bases. That is the probability of the particular mutation occurring as a function of the number of generations.PaulK writes: Wrong. That is the probability of a base being different from the original state, accounting for the fact that it could mutate back. And it applies to all bases, not just one.Models of DNA evolution - Wikipedia Wikipedia writes:
Another blunder on your part.
The models described on this page describe the evolution of a single site within a set of sequences.Kleinman writes:
Oh my, do you think the generation is the random trial for DNA evolution and not the replication? In your limited understanding of population genetics, do you think there are no instances where there are more than single offspring in a given generation? Another blunder on your part.
Actually, if you understood this math, you would understand that is wrong. It is not the number of generations that should be plotted but the number of replications.PaulK writes: No, it isn’t wrong in that either. If you understood the model you would know that,Kleinman writes:
That's because at equilibrium the probability that the base at that site will be different than the base was originally will be 0.75 and the probability the base will be the original base is 0.25. These are the two probability equations from that link: That probability will be close to 1 at about 1e8 replicationPaulK writes: No, the probability never rises above 0.75, as can be clearly seen if you look at the graph. See the quote from the article above.P(A|A,,t)=1/4(1-e^{-8t}) and P(different|A,,t)=3/4(1-e^{-8t}) That graph is a plot of the second probability curve. You are correct on this point (mark this day on your calendar). That curve approaches an asymptote of 0.75, not 1, and that is the equilibrium point for that site. Too bad that DNA evolution is not an equilibrium process. What that equilibrium point represents is the point where each possible substitution has occurred at least once at that site. Go back and read this paragraph from the link: Floyd Reed writes:
By definition, the total probability of all possible outcomes must sum to one, something has to happen, even if it is nothing. So the probability of one or more events (at least one event) is one minus the probability that it did not mutate, which is the probability complement of P(0|\lambda) , which can be written as P(\neg0|\lambda) (the probability that there are not zero events given the expected number of events):Kleinman writes:
So, show us how to apply the Jukes-Cantor model to the Kishony experiment. You won't. I've shown you how to use that model to predict the Kishony experiment because when the Jukes-Cantor model reaches equilibrium, all it shows you is the number of replication necessary to reach that equilibrium and that number is simply 1/(mutation rate). But feel free to use this model to demonstrate how you are descended from bananas.
But this model is only valid for an evolutionary process of one mutation at a time in a sequential evolutionary processPaulK writes: By which you mean that your assertions are only valid in such a case. But that is obviously not what Jukes-Cantor is modelling.PaulK writes:
I'll wager I'll get a paper peer-reviewed and published on Markov chains and DNA evolution before you do. Why don't you write a paper using the Jukes-Cantor model showing that you are a direct descendent from bananas?
Failing to understand what the Jukes-Cantor model is actually modelling is bad enough. But the mathematical errors are also severe and fatal. Too bad you don’t understand the mathematics of Markov chains.
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PaulK Member Posts: 17993 Joined: Member Rating: 5.6 |
quote: We are discussing the implications of the model which does reach an equilibrium. If you have to deviate from the model to make your point then you’re wrong. And that would be true even if your objection had merit.
quote: Only if a blunder is being right when Kleinman is stupidly wrong. The mathematical model describes how a single site evolves - and it is applied to all sites. The idea that only one site can mutate while all the others cannot change is not part of the model and has no basis in biology.
quote: Of course I realise that there can be multiple offspring, but that really doesn’t affect the point. For instance the number of siblings your father had makes no difference to your DNA.
quote: I’m glad I managed to set you right on this.
quote: What that equilibrium point represents is the point where the initial state has no influence on the final state, and that is rather important for understanding why 50,000,000 generations is the longest time the model could show. There is no way it could give a time of 500,000,000 generations as you claimed. Indeed, without other evidence you couldn’t conclude any relationship at all if the genomes had diverged so far.
quote: There would be ways to apply it, but certainly it should not be applied to the particular mutations that grant resistance because the model is not about selection at all. It could, however be applied to other changes in the DNA - which will occur (yes, even in the Kishony experiment there will be other mutations). Your failure to understand what the model represents is your error, not a fault in the model.
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Kleinman Member (Idle past 633 days) Posts: 2142 From: United States Joined: |
Kleinman writes:
Go for it PaulK, show us how to use the Jukes-Cantor model and that you are a direct descendent to bananas. What a surprise, a fish-to-mammals aficionado thinks that DNA evolution is an equilibrium process. Just one more reason that shows you are a mathematically incompetent bungler.PaulK writes: We are discussing the implications of the model which does reach an equilibrium. If you have to deviate from the model to make your point then you’re wrong. And that would be true even if your objection had merit.quote: Kleinman writes:
Even to the non-homologous portions of the genome? So that's why you think you are a direct descendent to bananas.
Are you sure you want to do this PaulK. I mean you are making one mathematical blunder after another. The Juke-Cantor describes DNA evolution at just a single site, not to all bases.Models of DNA evolution - Wikipedia PaulK writes: Only if a blunder is being right when Kleinman is stupidly wrong. The mathematical model describes how a single site evolves - and it is applied to all sites. The idea that only one site can mutate while all the others cannot change is not part of the model and has no basis in biology.Kleinman writes:
Oh? So the Jukes-Cantor model only applies to a single individual? I'm beginning to believe that you are a direct descendant of bananas.
Oh my, do you think the generation is the random trial for DNA evolution and not the replication? In your limited understanding of population genetics, do you think there are no instances where there are more than single offspring in a given generation? Another blunder on your part.PaulK writes: Of course I realise that there can be multiple offspring, but that really doesn’t affect the point. For instance the number of siblings your father had makes no difference to your DNA.Kleinman writes:
Do you know how to solve the Jukes-Cantor model without assuming a Poisson distribution? I bet you don't.
That's because at equilibrium the probability that the base at that site will be different than the base was originally will be 0.75 and the probability the base will be the original base is 0.25.PaulK writes: I’m glad I managed to set you right on this.Kleinman writes:
This is really pathetic. Each state of a Markov chain process only depend on the previous state of the system, all other states have no effect.
What that equilibrium point represents is the point where the initial state has no influence on the final state, and that is rather important for understanding why 50,000,000 generations is the longest time the model could show. There is no way it could give a time of 500,000,000 generations as you claimed. Indeed, without other evidence you couldn’t conclude any relationship at all if the genomes had diverged so far.PaulK writes: What that equilibrium point represents is the point where the initial state has no influence on the final state, and that is rather important for understanding why 50,000,000 generations is the longest time the model could show. There is no way it could give a time of 500,000,000 generations as you claimed. Indeed, without other evidence you couldn’t conclude any relationship at all if the genomes had diverged so farKleinman writes:
So when are you going to submit your paper for publication that shows that the Jukes-Cantor model says you are directly related to bananas?
So, show us how to apply the Jukes-Cantor model to the Kishony experiment. You won'tPaulK writes: There would be ways to apply it, but certainly it should not be applied to the particular mutations that grant resistance because the model is not about selection at all. It could, however be applied to other changes in the DNA - which will occur (yes, even in the Kishony experiment there will be other mutations). Your failure to understand what the model represents is your error, not a fault in the model.
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PaulK Member Posts: 17993 Joined: Member Rating: 5.6 |
quote: The non-homologous parts - if there are any - are as free to mutateAs any other parts. What that has to do with the discussion I can’t say,
quote: The Jukes-Cantor method is used to compare the genomes of individuals, as well as to consensus genomes constructed from multiple individuals.
In a molecular systematic analysis, the haplotypes are determined for a defined area of genetic material; a substantial sample of individuals of the target species or other taxon is used; however, many current studies are based on single individuals
Molecular Phylogentics quote: You can’t even get the maths right. Before the equilibrium state the probability that the base has not changed from the original is > 0.25. That is a bias in favour of the original state. The rest of the consequences are also correct. You cannot derive any number of generations > 50,000,000 from the method, with the chosen parameter. And certainly not 500,000,000 however many changes there are in the genome. That you claim otherwise is just your ignorance.
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Kleinman Member (Idle past 633 days) Posts: 2142 From: United States Joined: |
PaulK writes:
Nothing if you want to claim that you are related to bananas.
Only if a blunder is being right when Kleinman is stupidly wrong. The mathematical model describes how a single site evolves - and it is applied to all sites. The idea that only one site can mutate while all the others cannot change is not part of the model and has no basis in biology.Kleinman writes: Even to the non-homologous portions of the genome?PaulK writes: The non-homologous parts - if there are any - are as free to mutateAs any other parts. What that has to do with the discussion I can’t say,
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PaulK Member Posts: 17993 Joined: Member Rating: 5.6 |
So no substantive reply. What a surprise. Not.
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Kleinman Member (Idle past 633 days) Posts: 2142 From: United States Joined: |
PaulK writes:
If you are dumb enough to believe that you can ignore the non-homologous portions of genomes to do DNA phylogenetics, that's the only reply you deserve. Go publish a paper showing you are a direct descendent of bananas.
Only if a blunder is being right when Kleinman is stupidly wrong. The mathematical model describes how a single site evolves - and it is applied to all sites. The idea that only one site can mutate while all the others cannot change is not part of the model and has no basis in biology.Kleinman writes: Even to the non-homologous portions of the genome?PaulK writes: The non-homologous parts - if there are any - are as free to mutateAs any other parts. What that has to do with the discussion I can’t say,Kleinman writes: Nothing if you want to claim that you are related to bananas.PaulK writes: So no substantive reply. What a surprise. Not.
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jar Member (Idle past 137 days) Posts: 34140 From: Texas!! Joined: |
Kleinman writes: Go publish a paper showing you are a direct descendent of bananas. And so you continue to post utter nonsense and misrepresent all that folk have attempted to teach you. That is classic Christian Cult of Ignorance behavior.
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PaulK Member Posts: 17993 Joined: Member Rating: 5.6 |
And still no substantive answer.
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Kleinman Member (Idle past 633 days) Posts: 2142 From: United States Joined: |
Kleinman writes:
Have you sobered up yet? All you have to do is cherry-pick the correct homologous gene from a banana, plug it into the Jukes-Cantor model, and voil, you have bananas in your family tree. Who knew that bananas grow on a tree?
Go publish a paper showing you are a direct descendent of bananas.jar writes: And so you continue to post utter nonsense and misrepresent all that folk have attempted to teach you. That is classic Christian Cult of ********* behavior.
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Kleinman Member (Idle past 633 days) Posts: 2142 From: United States Joined: |
PaulK writes:
jar will help you on you bananas-to-humans family tree. And you aren't the only one who thinks he's a banana! And still no substantive answer.https://www.youtube.com/watch?v=hmmi7QB33qk
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jar Member (Idle past 137 days) Posts: 34140 From: Texas!! Joined: |
And yet again, all you can do is misrepresent what people have been trying to teach you.
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Trump won  Suspended Member (Idle past 1537 days) Posts: 1928 Joined: |
ironically this dust-up with kleinman and the evolutionists underline my point exactly
not only does the casual not understand what the heck any of you are saying you're literally vapidly chattering nonsense at each other you've outjuked the juke's-cantor cantor and it's bananas this site has become an absurdity i guess it always was, but when i joined in 03 as a teen, i was more naive to the psychopathetic nature of the s@#$-libs and fringe creationists Edited by a servant of Christ, : profanity Edited by a servant of Christ, : No reason given.
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Kleinman Member (Idle past 633 days) Posts: 2142 From: United States Joined:
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jar writes:
Is jar going to teach us how fish evolve into mammals? jar, you need to lay off the juice. You are starting to suffer from the DTs.
And yet again, all you can do is misrepresent what people have been trying to teach you.
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Kleinman Member (Idle past 633 days) Posts: 2142 From: United States Joined: |
a servant of Christ writes:
Very few creationists understand introductory probability theory either. Don't make the mistake that something you don't understand is absurd. It makes you sound like one of those fish-to-mammals aficionados.
ironically this dust-up with kleinman and the evolutionists underline my point exactlynot only does the casual not understand what the heck any of you are saying you're literally vapidly chattering nonsense at each other you've outjuked the juke's-cantor canter and it's bananas this site has become an absurdity i guess it always was, but when i joined in 03 as a teen, i was more naive to the psychopathetic nature of the s@#$-libs and fringe creationists
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