Here is an interesting study entitled: "A Key Detail in Some People's Childhoods May Lead to Vaccine Resistance"
"When we compared the early life histories of those who were vaccine resistant to those who were not we found many vaccine-resistant adults had histories of adverse experiences during childhood, including abuse, maltreatment, deprivation or neglect, or having an alcoholic parent.
These experiences would have made their childhood unpredictable and contributed to a lifelong legacy of mistrust in authorities, as well as seeding the belief that "when the proverbial hits the fan you're on your own".
This study, based in New Zealand, needs to be expanded, but if valid for a sizable percentage of anti-science/anti-authority people it suggests that it will be difficult to change minds. The article does point out that although NZ has many anti-vaxxers, 95 percent of its population is vaccinated and its infection rate and death rate are far lower than the US. It suggests why this may be so and thus offers some hope for improvement of the US, Canadian, and European situation.