Welcome to EvC, dude!
You dead right with your point about familiarity with ones territory. Anxiety patients almost universally feel better in some locations they count as home ground and feel higher levels aof anxiety in places where they do not have an 'escape route'.
I'm not so sure that it is hard wired into our brains, though. I would suggest that natural places are often devoid of people and it is this that makes us feel more at ease.
Also, we often take holidays in areas of outstanding natural beauty and we can learn the association between such places and rest and relaxation.
I bet when you talk about nature being so relaxing you don't mean the type of nature you would find on Dartmoor in the freezing rain and no shelter
That said, when ever I have a shroom trip I always prefer to be in a 'natural surrounding' because I get the sense that there are less people around to weird me out.
Edited by Larni, : No reason given.