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I'm still looking into this, but according to Josephus, Alexander the Great was shown a prophecy about him when he came through, it was either Daniel, or Zechariah. So here would be evidence that it was written during his time at least. And if that is the case, it still predicted the division between his four generals.
Josephus was writing more than 400 years after the events. We can't even assume that the story is true, let alone that it refers to a specific book. It certainly isn't evidence that the Book of Daniel was written at that time. And any claim that the Book of Daniel predicted an event requires that the book was written before that event. There's stronh evidence that Daniel wasn't written until long after Alexander's Empire was divided.
I've started a new topic on whether the Book of Daniel centres on the Greek or Roman Empires. I hope you'll be there to back up your claim that Daniel focusses on Rome.