I think the "reality" is that if you expect the "Truth" to be found in the different versions of scripture, you will see it. If you are looking for "problems" in the different versions, you will find those as well. The important difference between the two is that those looking for problems will find maybe 5 or 6 that seem significant and use those as a way to discredit the Single-column, 1888 pages in the Bible.
I have a 6 version bible, around here somewhere, with 6 columns accross 2 pages. It never caused me any confusion.