Damnedest thing, that. Every time someone comes up with a potential (or supposed) falsification it turns out the thing is actually supportive.
So, to answer your question: No, not yet. But we keep working at it.
The newest "final nail-in-the-coffin" of the TOE about to come charging onto the scene appears to be the development of instinct. Preliminary info seems to indicate this new devastating "nail" is the usual "too complex / incredulous / new 'law' just developed from nothing" mix, though.
Still, it could get interesting.