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Author Topic:   Some mutations sound too good to be true
PaulK
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Posts: 17825
Joined: 01-10-2003
Member Rating: 2.2


Message 241 of 301 (246720)
09-27-2005 11:59 AM
Reply to: Message 239 by Faith
09-27-2005 11:52 AM


Re: beneficial and big
No, you are wrong to say that the cheetah's ahven't recovered their genetic variability. Partly thanks ot more recent - but less severe - bottlenecks the cheetahs are still suffering the effects but their variability has recovered to some extent.
Postulating greater genetic variability is not much help. Even the best case is still very bad.

This message is a reply to:
 Message 239 by Faith, posted 09-27-2005 11:52 AM Faith has replied

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 Message 246 by Faith, posted 09-27-2005 12:13 PM PaulK has not replied
 Message 247 by Faith, posted 09-27-2005 12:20 PM PaulK has replied

PaulK
Member
Posts: 17825
Joined: 01-10-2003
Member Rating: 2.2


Message 242 of 301 (246721)
09-27-2005 12:01 PM
Reply to: Message 240 by Faith
09-27-2005 11:53 AM


Re: Number of variants of given gene
The variability depends on the locus. Some genes vary more than others. IIRC some human genes associated with the immune system have well over 10,000 alleles. And humans have a relatively low genetic diversity.

This message is a reply to:
 Message 240 by Faith, posted 09-27-2005 11:53 AM Faith has replied

Replies to this message:
 Message 244 by Faith, posted 09-27-2005 12:08 PM PaulK has replied
 Message 255 by PaulK, posted 09-27-2005 4:04 PM PaulK has not replied

AdminBen
Inactive Member


Message 243 of 301 (246723)
09-27-2005 12:06 PM
Reply to: Message 239 by Faith
09-27-2005 11:52 AM


Re: beneficial and big
3) Likewise in the Bible story of the Flood the inhabitants of the ark are supposed to be the sole survivors - again there are not other populations to consider. The effective human population under the usual interpretation, then, would be 5. "Unclean" species would be reduced to 2 individuals - a situation nearly as bad as the cheetah bottleneck (and even worse under some YEC interpretations, where multiple species would be descended from a mere 2 individuals living 4500 years ago).
This is why YECs have to postulate a greater inbuilt genetic diversity in these few than we normally see these days. More genes for one trait for instance.
To PaulK and Faith:
This thread's going fast, and I'm very busy, so I don't have time to figure out who brought up what. So sorry in advance; I chose this post because it's the most recent as I'm checking now.
This thread is about data, not postulates. If people see data that suggsets something, let's talk about the data and how it fits into current scientific theory. There's no need to talk about any "postulates" or bible stories here.
Thanks.
This message has been edited by AdminBen, Tuesday, 2005/09/27 09:06 AM

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This message is a reply to:
 Message 239 by Faith, posted 09-27-2005 11:52 AM Faith has replied

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Faith 
Suspended Member (Idle past 1466 days)
Posts: 35298
From: Nevada, USA
Joined: 10-06-2001


Message 244 of 301 (246724)
09-27-2005 12:08 PM
Reply to: Message 242 by PaulK
09-27-2005 12:01 PM


Re: Number of variants of given gene
The variability depends on the locus. Some genes vary more than others. IIRC some human genes associated with the immune system have well over 10,000 alleles. And humans have a relatively low genetic diversity.
THIS is what I've been supposing but haven't known for sure. Thank you very much. THAT MANY alleles for one gene??? But that would depend on the number of individuals wouldn't it? That is, thinking of Noah and family, or his three sons and three daughters-in-law, who are the parents of all the rest of us, does that mean that they are limited to a maximum of 12 alleles for a particular gene among them or am I misunderstanding something?

This message is a reply to:
 Message 242 by PaulK, posted 09-27-2005 12:01 PM PaulK has replied

Replies to this message:
 Message 248 by PaulK, posted 09-27-2005 12:32 PM Faith has replied

Faith 
Suspended Member (Idle past 1466 days)
Posts: 35298
From: Nevada, USA
Joined: 10-06-2001


Message 245 of 301 (246725)
09-27-2005 12:10 PM
Reply to: Message 243 by AdminBen
09-27-2005 12:06 PM


Re: beneficial and big
OK Ben.

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Faith 
Suspended Member (Idle past 1466 days)
Posts: 35298
From: Nevada, USA
Joined: 10-06-2001


Message 246 of 301 (246726)
09-27-2005 12:13 PM
Reply to: Message 241 by PaulK
09-27-2005 11:59 AM


Genetic variability
No, you are wrong to say that the cheetah's ahven't recovered their genetic variability. Partly thanks ot more recent - but less severe - bottlenecks the cheetahs are still suffering the effects but their variability has recovered to some extent.
Can you describe this at the gene level? And has mutation been observed to be the cause of the increase?
Postulating greater genetic variability is not much help. Even the best case is still very bad.
That is what I would assume. Recovering genetic variability to the point that the cheetah is no longer threatened with extinction is just about impossible.
This message has been edited by Faith, 09-27-2005 12:15 PM

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Faith 
Suspended Member (Idle past 1466 days)
Posts: 35298
From: Nevada, USA
Joined: 10-06-2001


Message 247 of 301 (246728)
09-27-2005 12:20 PM
Reply to: Message 241 by PaulK
09-27-2005 11:59 AM


Genetic variability, cheetah
No, you are wrong to say that the cheetah's ahven't recovered their genetic variability. Partly thanks ot more recent - but less severe - bottlenecks the cheetahs are still suffering the effects but their variability has recovered to some extent.
Oops, I think I misread this the first time around. Now it appears you are saying that more recent bottlenecks have increased their variability? But this can't be so. A bottleneck always reduces genetic variability.

This message is a reply to:
 Message 241 by PaulK, posted 09-27-2005 11:59 AM PaulK has replied

Replies to this message:
 Message 250 by PaulK, posted 09-27-2005 12:47 PM Faith has replied

PaulK
Member
Posts: 17825
Joined: 01-10-2003
Member Rating: 2.2


Message 248 of 301 (246731)
09-27-2005 12:32 PM
Reply to: Message 244 by Faith
09-27-2005 12:08 PM


Re: Number of variants of given gene
For noah's familiy without mutations the sons would have no genes that weren't presnet in their father or their mother. Assuming a single mother (as seems to be typical) that's an effective population of 5. So you're down to 10 possible variants for each gene. At most.

This message is a reply to:
 Message 244 by Faith, posted 09-27-2005 12:08 PM Faith has replied

Replies to this message:
 Message 257 by Faith, posted 09-27-2005 4:22 PM PaulK has not replied

AdminBen
Inactive Member


Message 249 of 301 (246737)
09-27-2005 12:44 PM
Reply to: Message 232 by Faith
09-27-2005 11:34 AM


Re: Does mutation actually increase variability?
Faith,
First off, I wanted to apologize up front for having to address admin issues twice in the same morning. If I had more time, and if this thread was going a little slower, I could have been more careful. I'm struggling to keep up. So, I apologize for posting twice, that may be discouraging.
Nonetheless, the issues I see are really important to me, and I want to be REALLY clear and consistent with these things. So please bear with me and look through the two issues I'm bringing up below:
First, I think you're really starting to approach things from a YEC perspective. That can't happen here. I saw this a bit in the post I brought up before, but there are two more posts that I ran across that made me really feel that things are moving in the wrong direction:
http://< !--UB EvC Forum: Some mutations sound too good to be true -->http://EvC Forum: Some mutations sound too good to be true
http://< !--UB EvC Forum: Some mutations sound too good to be true -->http://EvC Forum: Some mutations sound too good to be true
As usual, I will run on about why this is critical:
In the future, YECs may be able to come up with a set of postulates or theorems that explain all scientific data and also are consistent with the Bible. There are no such set of postulates.
Furthermore, even if that happens, current scientific theory is not invalidated in any way--only new observations can do that. All that will provide is a vialbe alternative.
The point is, all discussion here is whether or not current scientific theory can explain all of the current empirical evidence and, if so, how? Discussing alternative frameworks is outside of the scope of this thread.
I was disappointed to see that you're starting to use this thread as a way to think about alternative hypotheses. Your job, in this thread, is exactly what I said above: to discuss whether or not current scientific theory can explain all of the current empirical evidence and, if so, how. In these threads, current scientific theory stands, or falls, on it's own. We're going to use OTHER threads to discuss alternative approaches.

Second, I'm also becoming worried about the way you're wording things and how you're thinking about things here:
http://< !--UB EvC Forum: Some mutations sound too good to be true -->http://EvC Forum: Some mutations sound too good to be true
You are claiming that mutation alone increases genetic variability but only over great great periods of time -- in 10,000 years it has not rescued the cheetah
It is OK to use words to distance yourself from this "claim", because you feel there is an inconsistency (that you describe lower in the post). The inconsistency is based on two pieces of data and / or scientific theory.
This is a good, logical approach in my eyes.
and you consider 10,000 years to be a small period of time
When discussing science, we ALL consider 10,000 years to be a small period of time. There are no young earth thinkers in science. To honestly think through the science, Faith, you have to reason using the conclusions found by science.
By distancing yourself from this conclusion, you're moving away from scientific discussion (in my eyes). When we discuss science, we ALL use the same basic conclusions (theories). Even if it has to be an "intellectual game" for you, you need to do this.
It may seem nitpicky, but even if I'm in some way wrong, it's important: this is one of the ways I've seen things move quickly away from scientific discussion and into verbal wars about young-earth vs. old-earth. And I know that's the last thing any of us want--more pointless verbal wars. It really does take a high level of vigilence in the words that are written. But it is critically important.

Faith, please address any inquiries / comments about the contents of this post to the "General discussion..." thread linked below. We can talk about any of this there.
Thanks.

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This message is a reply to:
 Message 232 by Faith, posted 09-27-2005 11:34 AM Faith has not replied

PaulK
Member
Posts: 17825
Joined: 01-10-2003
Member Rating: 2.2


Message 250 of 301 (246738)
09-27-2005 12:47 PM
Reply to: Message 247 by Faith
09-27-2005 12:20 PM


Re: Genetic variability, cheetah
That's not quite correct. I'm saying that more recent bottlenecks have inhibited the recovery. (As a matter of simple logic the more recent bottlenecks would have had little effect unless genetic diversity were recovering)

This message is a reply to:
 Message 247 by Faith, posted 09-27-2005 12:20 PM Faith has replied

Replies to this message:
 Message 253 by Faith, posted 09-27-2005 3:03 PM PaulK has replied

Wounded King
Member
Posts: 4149
From: Cincinnati, Ohio, USA
Joined: 04-09-2003


Message 251 of 301 (246742)
09-27-2005 1:44 PM
Reply to: Message 218 by Graculus
09-26-2005 9:27 PM


It's that bug again!!
The flavobacterium mutation that produced the nylon bug was a frame shift.
This is somewhat of an exaggeration in a couple of ways. Firstly the enzyme covered in the frameshift paper (Ohno, 1984) is only one of three on the plasmid conferring nylon digesting abilitites, although all three are not required. Secondly the paper only shows that there is a possible long Open Reading Frame which can be produced by a hypothetical reverse frame shift mutation. There is no actual ancestral pre-mutation sequence which has been identified allowing a comparison. If this particular topic interests you there is another thread on it here.
TTFN,
WK
This message has been edited by Wounded King, 09-27-2005 01:44 PM

This message is a reply to:
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nator
Member (Idle past 2192 days)
Posts: 12961
From: Ann Arbor
Joined: 12-09-2001


Message 252 of 301 (246748)
09-27-2005 2:38 PM
Reply to: Message 235 by Faith
09-27-2005 11:44 AM


Re: mutation and variability
quote:
Unless the change is deleterious or produces disease.
Is my lack of bottom wisdom teeth deleterious?

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 Message 235 by Faith, posted 09-27-2005 11:44 AM Faith has replied

Replies to this message:
 Message 254 by Faith, posted 09-27-2005 3:13 PM nator has replied

Faith 
Suspended Member (Idle past 1466 days)
Posts: 35298
From: Nevada, USA
Joined: 10-06-2001


Message 253 of 301 (246753)
09-27-2005 3:03 PM
Reply to: Message 250 by PaulK
09-27-2005 12:47 PM


Re: Genetic variability, cheetah
That's not quite correct. I'm saying that more recent bottlenecks have inhibited the recovery. (As a matter of simple logic the more recent bottlenecks would have had little effect unless genetic diversity were recovering)
OK, I get it now. Somehow it looked ambiguous on second reading, but I see my error now.
But not ALL their genes were fixed, so how is their having some effects from more recent bottlenecks a proof that they had recovered diversity -- as opposed to losing what little they still had?

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 Message 250 by PaulK, posted 09-27-2005 12:47 PM PaulK has replied

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Faith 
Suspended Member (Idle past 1466 days)
Posts: 35298
From: Nevada, USA
Joined: 10-06-2001


Message 254 of 301 (246756)
09-27-2005 3:13 PM
Reply to: Message 252 by nator
09-27-2005 2:38 PM


Re: mutation and variability
Is my lack of bottom wisdom teeth deleterious?
I tend to think of anything's being missing as a negative effect of mutation, don't you? But of course under some circumstances it can confer a benefit, and in this case it appears to be neutral as far as consequences go.

This message is a reply to:
 Message 252 by nator, posted 09-27-2005 2:38 PM nator has replied

Replies to this message:
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 Message 273 by nator, posted 09-28-2005 8:01 AM Faith has not replied

PaulK
Member
Posts: 17825
Joined: 01-10-2003
Member Rating: 2.2


Message 255 of 301 (246764)
09-27-2005 4:04 PM
Reply to: Message 242 by PaulK
09-27-2005 12:01 PM


Re: Number of variants of given gene
quote:
IIRC some human genes associated with the immune system have well over 10,000 alleles
Having tried to check my memory it appears that I was in error. The highest number I have found is 1300.

This message is a reply to:
 Message 242 by PaulK, posted 09-27-2005 12:01 PM PaulK has not replied

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