Is Human DNA as good as it gets?

We are not at the top of the food chain; insects and bacteria are. They eat us.I am pretty sure (but don't know) that by some measures of complexity (number of genes, chromosomes, base pairs) we are not the most complex. It may well be that by other measure we are but I don't think that is known yet. Yes and no. The totality of the gene pool of all organisms is a record of all that has gone before and the enviroments they adapted to. However, the record has been written over and written over again and as you go back it is more jumbled like a palpimset (sp?) that has been used more than once.

You'd have to supply the source for that statment. There seem to be a lot of cases where it has changed.There is reason to think that the black death supplied enough selective pressure that europeans (and other subject to it) carry some mutations that others don't.That is the kind of evolution that we would expect to see over the 10,000 year time frame. This sort of thing will, of course, be reduced by a much larger, interacting population.