As pointed out later, it depends on the proteins produced. However, in one of the most famous and documented cases of evolution by natural selection, the mutation was immediately apparent. The first notice of a dark morph in the Peppered moth (Biston betularia) was in 1848. Until then all observed moths had been of the light-speckled variety. From then until 1895 the percentage of dark morphs increased until it had reached 95% in polluted areas. As pollution was reduced during the last half of the 20th century, the number of dark morphs also declined.
My point here is that the dark morph (called carbonaria) was caused by a single point mutation. The mutation and the gene has been identified. The mutated gene is dominant. Thus, heterozygous moths are dark.
Should we regard that as evidence that humans descended from ape like animals over millions of years?