jar writes:
Is there a reasonable scenario for Humans to become split and isolated over a period of time long enough to result in two separate species other than our moving off world?
I think the most likely scenario of this happening so far is presented in the movie The Time Machine remake. The moon breaks up and falls on us. A part of the population goes under ground to escape the disaster while the other part remains on the surface. Life for both groups undoubtedly becomes very harsh.
After centuries of living under ground, the first group has adopted well enough that they don't want to go back to the surface. The second group has also survived and begins to thrive again on the planet surface.
After 800 thousand years, we effectively have 2 different species of humans.
As the vampire-like under ground human sub-species tells our time traveler, "Who are you to question 800 thousand years of evolution?"
Other than this scenario, I can't really think of any other way we could prevent gene flow from happening for long enough for the human species to split into two.
Disclaimer:
Occasionally, owing to the deficiency of the English language, I have used he/him/his meaning he or she/him or her/his or her in order to avoid awkwardness of style.
He, him, and his are not intended as exclusively masculine pronouns. They may refer to either sex or to both sexes!