Crash's comments about obsevation are meaningful. There is work going on trying to figure out what may have lead to that first domino falling.
I disagree with Crash a little though. The first domino is not the same as all the rest. It is like a inductive proof in that regard. You do have to separately demonstrate the starting point.
Once the domino's are falling then we have evolution. Clearly the question of getting them falling is difficult. It isn't like evolution where we see so much remaining evidence of past occurances and have things to test today. We are having to probe back over 3 billion years and try to see what happened then (or may have happened).
If you want to google you will find experiments on self replicators and other reductionist approaches to this problem. I think you will also find reference in threads discussing the issue here.