|"You have loaded yourself with an unnecessary difficulty in adopting Natura non facit saltum so unreservedly."|
|- T.H. Huxley,|
to Darwin (Huxley 1900, 2:27)
he principle of evolutionary opportunism is closely related to evolutionary history and to the effects of contingency (some authors refer to the concept of opportunism as "the principle of continuity") (Crick 1968). Descent with gradual modification means that new organisms can only use and modify what they initially are given; they are slaves to their history. New structures and functions must be recruited from previous, older structures (Futuyma 1998, pp. 110, 671-674). This is because structures, as opposed to functions, are strictly inherited. True unprecedented structural novelty should be very rare. This provides extreme constraints on the possible paths of evolution, as Huxley well noted in the quote above.
One major consequence of the constraint of gradualism is the predicted existence of paralogy. Paralogy, as the term is used here, is similarity of structure despite difference in function. When one species branches into two species, one or both of the species may acquire new functions. Since the new species must recruit and modify preexisting structures to perform these new functions, the same structure shared by these two species will now perform a different function in each of the two species. This is paralogy. It follows that paralogous structures have a history that should be explicable from other lines of evolutionary evidence, since derived characteristics (which is what these new functions and structures now are) have evolved from more primitive (i.e. older) structures. Consequently, detailed and explicit predictions can be made about the possible morphologies of fossil intermediates.
Figure 3.11.1. Comparison of the forelimbs of various relatives of modern birds. Forelimbs of (A) Ornitholestes, a theropod dinosaur, (B) Archaeopteryx, (C) Sinornis, an archaic bird from the lower Cretaceous, and (D) the wing of a modern chicken (modified from Carrol 1988, p. 340; Carrol 1997, p. 309).
An equivalent way of stating the principle of evolutionary paralogy is that the predicted phylogenetic tree must have structural continuity, as opposed to functional continuity. Structures and patterns are inherited, but not necessarily functions. As one follows the line from ancestor through descendants, the functions and forms can come and go, but the underlying structures must grade from one into another, relatively unchanged.
There are countless examples of paralogy in living and extinct species – the same bones in the same relative positions are used in primate hands, bat wings, bird wings, pterosaur wings, whale and penguin flippers, horse legs, the digging forelimbs of moles, and webbed amphibian legs. All of these characters have similar structures that perform various different functions. The standard phylogenetic tree shows why these species have these same structures, i.e. they have common ancestors that had these structures. This is the conclusion supported by the phylogenetic tree, even though these paralogous characters were not used to group these species together. Viewed objectively, this is truly a remarkable result, since only shared derived characters, which have the same structure and function, determine which species are grouped together in a phylogeny (refer to the explanation of cladistic methodology for more discussion).
Additionally, independent evidence from the fossil record has confirmed that many of those structures were derived from others. The fossil record shows a general chronological progression of intermediate forms between theropod dinosaurs and modern birds, in which theropod structures were modified into modern bird structures (Carrol 1988; Carrol 1997; Sereno 1999). This series is exemplified by Eoraptor (~230 Mya), the Herrerasauridae (~230-210 Mya), the Ceratosauria (~220-65 Mya), the Allosauroidea (180-90 Mya), the Deinonychosauria (150-65 Mya), Archaeopteryx (~150 Mya), the Confuciusornithidae (145 Mya), the Enantiornithes (145 Mya-65 Mya), and the Euornithes (65 Mya-recent) (Serreno 1999). Figure 3.11.1 shows the forelimbs of four representative intermediates of the avian lineage (Carrol 1988, p. 340; Carrol 1997, p. 309).
The fossil record could show a chronological progression in which bird wings are gradually transformed into reptilian arms; however, the opposite is the case. Additionally, a strong falsification would be if it were positively demonstrated that the primitive structures of an organism's predicted ancestors could not be reasonably modified into the modern organism's derived structures. A clear fanciful example, though completely serious, is the macroevolutionary impossibility of ever finding an animal such as a Pegasus. Since a Pegasus would be a mammal closely related to the horse, its wings would be considered derived characters. However, Pegasus wings cannot be modifications of its ancestors' structures, since the immediate predicted ancestors of Pegasi and horses had no possible structures there to modify (Futuyma 1998, p. 110).
Analogously, we predict that we should never find birds with both wings and
arms, or mollusks harboring chloroplasts, even though these structures could be
quite useful for these organisms. Equivalently, it would be a strong
falsification if the phylogenetic tree had no structural continuity, but rather
had functional continuity or had no recognizable continuity of any kind. Also
see the falsification for prediction
The concept of paralogy applies equally to both the macroscopic structures of organisms and structures on the molecular level.
On the molecular level, the existence of paralogy is quite impressive. Many proteins of very different function have strikingly similar amino acid sequences and three-dimensional structures. A frequently cited example is lysozyme and α-lactalbumin. Almost all animals have lysozyme. It is a secreted protein used to degrade bacterial cell walls as a means of defense (Voet and Voet 1995, p. 381). α-Lactalbumin is very similar structurally to lysozyme, even though its function is very different (it is involved in mammalian lactose synthesis in the mammary gland) (Acharya, Stuart et al. 1989; Voet and Voet 1995, p. 608). It can often be inferred from molecular phylogenies, as it has been here, that the protein with the more basic function (e.g. lysozyme) is also the older protein (Prager and Wilson 1988; Qasba and Kumar 1997).
On a grander scale, a stunning confirmation of these evolutionary predictions has come from an analysis of Saccharomyces cerevisiae (baker's yeast) and Caenorhabditis elegans (a worm). The genomes of both these organisms were sequenced very recently (Barrell 1996; Consortium 1998). The genes used by the yeast, a unicellular organism, are mostly genes dealing directly with core biochemical functions that all organisms must perform. From an evolutionary perspective, we would expect these genes to be ancient. Thus it was expected and shown that the worm contains a great majority of these genes. In contrast, the extra genes used by the worm, which deal with multicellularity, should be more recently evolved. Phylogenetic analysis has shown that this is exactly the case. The vast majority of extra genes in the worm appear to be directly derived from genes providing core cellular functions, in accordance with evolutionary prediction (Chervitz 1998).
Proteins performing more recently evolved functions should have statistically
significant similarities with proteins performing core functions. It is
evolutionarily problematic if they do not. Furthermore, it would be inconsistent
with evolutionary theory if we had found that genes involved in multicellular
functions were more deeply rooted in their phylogenies (i.e. if these genes were
more ancient than the core function genes) (Li 1997; Chervitz 1998).
A corollary of the principle of evolutionary opportunism is analogy. Analogy is the case where different structures perform the same or similar functions in different species. Two distinct species have different histories and different structures; if both species evolve the same new function, they may recruit different structures to perform this new function. Analogy also must conform to the principle of structural continuity; analogy must be explained in terms of the structures of predicted ancestors.
There are many anatomical examples of functional analogy. One case is the vertebrate eye and the cephalopod eye. Another, mentioned earlier, is the case of American and Saharan desert plants, which use different structures for the same functions needed to live in dry, arid regions. Certain mammals (whales, manatees, dolphins), birds (penguins), and fish all have the ability to live and swim in aquatic environments, and they obviously use different structures overall for these aquatic functions. Although now modified, all of the structures that perform these functions were also present in their predicted ancestors.
We would not expect newly discovered species of dolphins, whales, penguins,
or any close mammalian relatives to have gills (a possible analogy with fish),
since their immediate ancestors lacked gills or gill-like structures from which
they could be derived. This is the macroevolutionary prediction, in spite of the
fact that gills would be extremely advantageous for aquatic mammals and birds.
Also see the falsification below for molecular analogy, point
Like paralogy, analogy should be represented on both macroscopic and molecular levels.
A familiar molecular example is the case of the three proteases subtilisin, carboxy peptidase II, and chymotrypsin. These three proteins are all serine proteases (i.e. they degrade other proteins in digestion). They have the same function, the same catalytic residues in their active sites, and they have the same catalytic mechanism. Yet they have no sequence or structural similarity (Voet and Voet 1995, p. 394).
Another molecular example is that of DNA polymerases. DNA polymerases are the proteins that catalyze the duplication of a strand of DNA; i.e. they catalyze multiple additions of nucleotides to a DNA strand. All the structures determined for DNA polymerases have clear structural similarity except for one, rat polymerase β (Davies, Almassey et al. 1994; Voet and Voet 1995, p. 1040). Except for rat polymerase β, all the DNA polymerases are most likely related by divergent evolution. Rat polymerase β has structural similarity with nucleotidyl transferases, which catalyze the addition of one nucleotide to a DNA strand. Rat polymerase β has obviously evolved from nucleotidyl transferases by mutating to catalyze several nucleotide additions instead of just one (which nicely illustrates why analogy is ultimately also paralogy) (Aravind and Koonin 1999).
Paralogy and analogy are specific predictions of macroevolution and the
principle of evolutionary opportunism. It is possible that a world could exist
where there were no cases of biological paralogy or analogy. For example, living
organisms could be constructed in a modular manner, like most anthropogenic
creations, where each specific structure performs one specific function.
Another consequence of evolutionary opportunism is the existence of apparent suboptimal function. As stated before, in evolving a new function, organisms must make do with what they already have. Thus, functions are likely to be performed by structures that would have been arranged differently (e.g. more efficiently) if the final function were known from the outset. "Suboptimal function" does not mean that a structure functions poorly. It simply means that a structure with a more efficient design (usually with less superfluous complexity), could perform the same final function equally as well. Structures with suboptimal function should have a gradualistic historical evolutionary explanation, based on the opportunistic recruitment of ancestral structures, if this history is known from other evidence (e.g. if this history is phylogenetically determined by closely related organisms or fossil history).
Suboptimality and Irreducible Complexity
The appearance of suboptimal function is intimately related to the inference of Intelligent Design. Obviously, there are many inefficient ways to perform any given function; however, some functions are performed very efficiently. Those structures that perform extremely efficient functions are often intelligently designed. Similarly, we often think of the best designer as the one who designs a structure to perform a function the most elegantly, the most efficiently, and with the least needless complexity.
In the terms of the Intelligent Design advocate Michael Behe, one measure of efficiency of design (whether real or apparent) is irreducible complexity. Here are Behe’s own words – "By irreducibly complex (IC) I mean a single system composed of several well-matched, interacting parts that contribute to the basic function, wherein the removal of any one of the parts causes the system to effectively cease functioning." (Behe 1996, p. 39, emphasis in the original, my parentheses).
An equivalent way of stating the evolutionary prediction of suboptimal function is that many biological systems should not be irreducibly complex. Furthermore, in most biological cases an irreducibly complex system will not be the simplest irreducibly complex system that could perform the same function. For instance, the same function may be performed by two systems of unequal complexity in two different organisms. Comparative molecular biology has demonstrated that many non-redundant genetic systems (i.e. IC systems) in one given species indeed are performed by more simple systems in other organisms. Furthermore, in innumerable cases many, if not most, biological systems are in fact genetically redundant (i.e. they are not IC).
Note: The above point is not a refutation of Behe’s central argument that very complex IC systems are difficult to evolve gradually (Behe 1996, p. 40). Nevertheless, Behe’s thesis is not a rigorous scientific hypothesis, because it is very difficult, if not impossible, to marshal positive supporting evidence. One can positively establish that a system is not IC by removing a part and maintaining function. One can positively establish that a given system is not the simplest IC system by observing a functionally equivalent system with fewer parts in another organism. However, one cannot demonstrate that it is impossible to gradually evolve a certain IC system. This problem is especially grave since Behe readily admits that IC systems can evolve gradually (e.g. hemoglobin) (Behe 1996, pp. 40, 206-207). In fact, given enough iterations of evolutionary selection, there is theoretically a functional gradual path to any IC structure (Behe 1996, p. 40; Thornhill and Ussery 2000). Behe’s thesis thus boils down to a question of time, not of possibility. Despite this fact, Behe never considers evolutionary time constraints or rates of gradual evolution. For a consideration of the time necessary for observed evolutionary changes, see prediction 28 and prediction 29.
The mammalian gastrointestinal tract crosses the respiratory system. Functionally, this is suboptimal; it would be beneficial if we could breathe and swallow simultaneously. Unfortunately, we cannot, and this is why we are susceptible to death by choking. However, there is a good historical evolutionary reason for this arrangement. The Osteolepiformes (Devonian lungfish), from which mammals evolved, swallowed air to breathe. Only later did the ancestors of mammals recruit the olfactory nares of fish for the function of breathing on land. It so happens that the nares (originally used only for smelling) are on the opposite side of the esophagus from the lungs (Futuyma 1998, p. 5).
Another anatomical example of suboptimal function is the inverted mammalian retina, with its blind spot. It is inverted because the retinal blood vessels and nerves are situated on top of the retina, and light must travel through them first before hitting the light sensitive cells below. The blind spot is caused by the hole where the nerves all meet and pierce through the retina to travel to the brain. In order to deal with the many problems inherent in an inverted retina, the vertebrate eye utilizes various complex compensatory structures and mechanisms (e.g. foveas and slower, more transparent unmyelinated nerves).
Cephalopods (e.g. squids and octopi) have eyes with a similar form based on the same mechanistic principles as mammalian eyes. However, in contrast with mammalian eyes, cephalopod eyes have very different underlying retinal structures (e.g. they are verted, not inverted), and they have no blind spots (Goldsmith 1990; Williams 1992, pp. 72-74). This strongly suggests that mammals also could have eyes without blind spots.
There are many other examples of suboptimal function in the Jury-rigged Design FAQ.
A strong positive falsification would be the discovery of a mammal without crossed gastrointestinal and respiratory tracts, or a reptile or mammal without blindspots in its eyes, etc. This is because poor design cannot be "fixed" by evolutionary processes, even if correcting the problem would be beneficial for the organism. The only "fixing" that is allowed evolutionarily is relatively minor modification of what already exists.
Note: Members of this class of argument could conceivably be nullified
if a structure with a presumed suboptimal function were in fact found to be
functionally efficient. However, for most examples, finding an important
function for the specific structural arrangement does not alter the basic
conclusion. For example, perhaps the retinal blind spot in vertebrates is
actually necessary for an important function, or perhaps it has a presently
unknown function specific to land animals. In fact, some anti-evolutionists have
proposed that the complex inverted vertebrate eye, with its blind spot, is
required for terrestrial life, while the more efficient cephalopod verted eye is
sufficient for murky underwater vision (Bergman 2000). But then the question
arises – why do vertebrate fish have inverted eyes? For fish, the vertebrate eye
plan with its additional needless complexity is suboptimal, since the more
elegant, more efficient, less complex cephalopod eye could perform underwater
functions equally as well. The "suboptimal function" argument has not been
refuted; the emphasis has merely been shifted from one organism to another.
Moreover, the macroevolutionary hypothesis would still be potentially falsified
by the discovery of vertebrate bony fish with verted eyes. For more information
see the "Suboptimality and
Irreducible Complexity" box.
The principle of imperfect design should apply to biomolecular organization as well.
With the recent sequencing of the human genome, we have found that less than 2% of the DNA in the human genome is used for making proteins (International Human Genome Sequencing Consortium 2001, p. 900). A full 45% is composed of transposons, which serve no function for the individual (except to cause occasional genetic illnesses and increase the rate of cancer formation). One retrotransposon, LINE1, constitutes a full 17% of the human genome (Smit 1996, IHGSC 2001, p. 879-882).
20% of the human genome is pseudogenes. They also serve no function for the individual. A remarkable example is the glyceraldehyde-3-phosphate dehydrogenase (GDPH) gene. In humans, there is one functional GDPH gene, but there are at least twenty GDPH pseudogenes. In mice, there are approximately 200 GDPH pseudogenes, none of which are necessary. In addition to one or two functional copies, there are between 20 and 30 pseudogenes of cytochrome c in both humans and the rat (Li 1997, p. 349).
The majority of eukaryotic genes coding for functional proteins are interrupted by noncoding sequences called introns. Introns must be cut out before the information contained in the gene can be used to make protein. Introns make up 80% of the average vertebrate gene (Voet and Voet 1995, p. 1144). Similar to transposons, most introns serve no purpose (in rare cases they are involved in gene regulation or code for a functional RNA).
The rest of the DNA in a eukaryotic genome is mostly short repetitive sequences such as AAAAAA, CACACA, or CGGCGGCGG. These likewise serve no function for the individual, and thus they have even been termed junk DNA (IHGSC 2001, p. 879). It appears that there is no efficient mechanism for ridding a metazoan (animal) genome of extraneous DNA; once extra DNA is introduced into the genome of an animal, it is there to stay.
Even protists, unicellular organisms, are subject to such evolutionary jury-rigging. Two ciliates, Paramecium aurelia and Paramecium caudatum, are virtually indistinguishable from morphological and phenotypic analysis. However, the first has less than 200,000 kb of DNA in its genome, whereas the genome of the second has nearly 9,000,000 kb of DNA, which is evidently at least 45 times the amount it actually needs (Li 1997, p. 383). Note also that Paramecium caudatum, a single-celled organism, has about three times the DNA as a human.
A lot of wasted energy is expended in dealing with this useless DNA; however, all these molecular examples also have convincing explanations based on evolutionary histories. See the molecular nonfunctional evidence in predictions 19-21 for more information (Li 1997).
Because evolution has no foresight, and cannot plan for future functions, it would be extremely suspicious if biological molecular systems were efficiently designed. Again, this does not rule out complexity - merely efficiency of mechanism.
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