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Author Topic:   What all can you find out from DNA anyway?
Modulous
Member
Posts: 7801
From: Manchester, UK
Joined: 05-01-2005


Message 26 of 28 (791456)
09-15-2016 1:30 PM
Reply to: Message 17 by Faith
07-21-2016 11:18 PM


Of course I wonder how reliable the test is. What if there are people groups that have no identifying mutations?
Then you wouldn't be able to identify them from the DNA. This is an issue of resolution rather than reliability though. You can't see EVERYTHING from DNA, but that doesn't mean the information you can infer is unreliable.
It is, however, not 100% perfect.
Or, here's a specific question: the person who was tested has a Jewish ancestor who is half Northern/Eastern European/Ashkenazi and half Sephardic (Portuguese in this case) but the percentage given makes the ancestor about 97% Ashkenazi. Should this be explained as there being no particular Sephardic mutation?
Depends on the test, really. The Ashkenazi and Sephardic are very similar, typically coming out as quite close to Southern Europe (Italy, Greece, Spain) , for perhaps obvious reasons. A cheap test such as the 23andme test, only looks at a small selection of genetic markers and as said, the two groups are very similar to one another. Not sure if there is a definitive indicator that separates them but 23andme may simply not check it.
Or could it mean that the Sephardic ancestors had a lot of Ashkenazi ancestry they didn't know about?
From wiki:
quote:
In the case of Ashkenazi and Sephardi Jews (in particular Moroccan Jews), who are closely related, the source of non-Jewish admixture is mainly southern European. Behar and colleagues have remarked on an especially close relationship between Ashkenazi Jews and modern Italians.
...
"Ashkenazic and Sephardic Jews have roughly 30 percent European ancestry, with most of the rest from the Middle East." He further noticed that "The two communities seem very similar to each other genetically, which is unexpected because they have been separated for so long." Concerning this relationship he points to Atzmon's conclusions that "the shared genetic elements suggest that members of any Jewish community are related to one another as closely as are fourth or fifth cousins in a large population, which is about 10 times higher than the relationship between two people chosen at random off the streets of New York City"
. And should that unaccounted for 3% be supposed to come from a nonJewish ancestor?
Well, as an approximation, it probably suggests not that there is *A* non-Jewish ancestor, but that 3% of the ancestors were non-Jewish.
Also said person has a grandmother who is French. But the percentage of French in his test is minuscule, like 1.2%. Does that mean the French grandmother doesn't know her real genetic background or what?
Well said person only inherited about 25% of said grandmother's genes. Said grandmother is unlikely to have 100% northern European genetic markers (because Europe has had a lot of migration to and fro), and is certain to not have only genes that are characteristic of French.

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 Message 17 by Faith, posted 07-21-2016 11:18 PM Faith has not replied

Replies to this message:
 Message 27 by 14174dm, posted 09-15-2016 2:39 PM Modulous has replied

  
Modulous
Member
Posts: 7801
From: Manchester, UK
Joined: 05-01-2005


Message 28 of 28 (791464)
09-15-2016 4:06 PM
Reply to: Message 27 by 14174dm
09-15-2016 2:39 PM


Re: Question on inheriting
I was wondering - is the 25% of grandmother's genes an exact number or is it a rough approximation for the whole gene?
Neither. It's a very close approximation based on the law of large numbers. Genetic recombination is like thousands of coin tosses.
Is it physically possible but statistically unlikely that a person could get 50% of genes from maternal grandmother, 30% from paternal grandfather, 15% from maternal grandfather, and 5% from paternal grandmother?
Absolutely, but I think there are evolved genetic mechanisms that 'enforce' a 50% division so it's not left entirely to chance. There are however, many many complications.
I would assume that the statistics depend on which and how many genes are compared. The more comparisons, the closer to 25% each.
Indeed.

This message is a reply to:
 Message 27 by 14174dm, posted 09-15-2016 2:39 PM 14174dm has not replied

  
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