Understanding through Discussion


Welcome! You are not logged in. [ Login ]
EvC Forum active members: 116 (8795 total)
Current session began: 
Page Loaded: 10-17-2017 11:16 AM
349 online now:
Coragyps, DrJones*, GDR, Guido Arbia, jar, Meddle, PaulK, Phat (AdminPhat) (8 members, 341 visitors)
Chatting now:  Chat room empty
Newest Member: jaufre
Upcoming Birthdays: Astrophile
Post Volume:
Total: 820,745 Year: 25,351/21,208 Month: 978/2,338 Week: 99/450 Day: 23/34 Hour: 0/8

Announcements: Reporting debate problems OR discussing moderation actions/inactions


Thread  Details

Email This Thread
Newer Topic | Older Topic
  
Author Topic:   Random DNA Sequences Contain Information
Taq
Member
Posts: 7190
Joined: 03-06-2009
Member Rating: 3.2


Message 1 of 2 (815385)
07-19-2017 4:48 PM


What are the chances that a random DNA sequence will have beneficial function, and therefore information? A lot better than you may think.

A team of researches inserted random DNA sequences into E. coli and then tested to see if those random DNA sequences increased fitness. To their surprise, 25% of the random DNA sequences were beneficial as either RNA molecules or as proteins.

quote:
Random sequences are an abundant source of bioactive RNAs or peptides

Rafik Neme, Cristina Amador, Burcin Yildirim, Ellen McConnell & Diethard Tautz

Nature Ecology & Evolution 1, Article number: 0127 (2017)

http://www.nature.com/articles/s41559-017-0127?WT.mc_id=C...

It is generally assumed that new genes arise through duplication and/or recombination of existing genes. The probability that a new functional gene could arise out of random non-coding DNA is so far considered to be negligible, as it seems unlikely that such an RNA or protein sequence could have an initial function that influences the fitness of an organism. Here, we have tested this question systematically, by expressing clones with random sequences in Escherichia coli and subjecting them to competitive growth. Contrary to expectations, we find that random sequences with bioactivity are not rare. In our experiments we find that up to 25% of the evaluated clones enhance the growth rate of their cells and up to 52% inhibit growth. Testing of individual clones in competition assays confirms their activity and provides an indication that their activity could be exerted by either the transcribed RNA or the translated peptide. This suggests that transcribed and translated random parts of the genome could indeed have a high potential to become functional. The results also suggest that random sequences may become an effective new source of molecules for studying cellular functions, as well as for pharmacological activity screening.


Not only is information present in random DNA sequences, it is very common. This counters the ID claim that information can only come about if an intelligence puts it there.

Preferred forum: Biological Evolution


AdminNosy
Administrator
Posts: 4753
From: Vancouver, BC, Canada
Joined: 11-11-2003


Message 2 of 2 (815387)
07-19-2017 4:55 PM


Thread Copied to Biological Evolution Forum
Thread copied to the Random DNA Sequences Contain Information thread in the Biological Evolution forum, this copy of the thread has been closed.
Newer Topic | Older Topic
Jump to:


Copyright 2001-2015 by EvC Forum, All Rights Reserved

™ Version 4.0 Beta
Innovative software from Qwixotic © 2017