Hi Ifen,
Rather than an incurable plague or asteroid impact, how 'bout good ol' fashioned ecological collapse? Sort of, "not with a bang, but a whimper" scenario. I doubt that would eliminate all humanity, but the trend is there for the demise of
Homo technicus, I'd say.
For an interesting look at this concept, see for instance Ehrlich and Ehrlich 1981
Extinction (Random House), the ecosphere feedback loop theory of Levin 1999 in
Fragile Dominion (Perseus Books), or for something more recent, Diamond 2005
Collapse (Viking Press). I like the last one primarily because he talks about nature eventually sorting out the problem even if we don't do anything - in this case by deleting us.