Don't know where your head is at but if you want to wrap it around something profound, deep and edifying, try
The Prophet, Khalil Gibran. No facet of life is left out in this series of well crafted conversations.
Something a little lighter but still with intellectual purpose might be
The Mismeasure of Man, Stephen Jay Gould. Always loved his stuff.
But then you say you're going on vacation. So as long as you're relaxing your body and spirit, relax your brain:
David Barry's Money Secrets or
Babies and Other Hazards of Having Sex. Delightful little tittles.
For engrossing novels, if you haven't already done so, try Dan Brown's
The Da Vinci Code or Nelson DeMille's
The General's Daughter.
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