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Author Topic:   CSI and Evolution
NosyNed
Member
Posts: 9004
From: Canada
Joined: 04-04-2003


Message 16 of 23 (63139)
10-28-2003 2:23 PM
Reply to: Message 11 by Peter
10-28-2003 4:13 AM


We conclude that information-theoretic calculations of the present level of sophistication do not provide any useful insights into molecular biological sequences.
I certainly don't understand the abstract very much. However, I don't see "information-theoretic" calculations not applying means that I can't supply an "information" content to a DNA string. I simply don't see the difference between a string of base pairs and a string of letters or numbers.
What is wrong with my thinking here? What is an information-theoretic calculation anyway?

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 Message 11 by Peter, posted 10-28-2003 4:13 AM Peter has replied

Replies to this message:
 Message 17 by Peter, posted 10-29-2003 3:35 AM NosyNed has replied

  
Peter
Member (Idle past 1510 days)
Posts: 2161
From: Cambridgeshire, UK.
Joined: 02-05-2002


Message 17 of 23 (63259)
10-29-2003 3:35 AM
Reply to: Message 16 by NosyNed
10-28-2003 2:23 PM


My understnding o fthe paper is that they have considered
Shannon's mathematical calculations in biological terms
and eventually concluded that they don't really have any
explanatory power for genomes.
quote:
...means that I can't supply an "information" content to a DNA string. I simply don't see the difference between a string of base pairs and a string of letters or numbers.
That's a different matter -- all I was (and have elsewhere) said
is that Shannon's information theorem cannot be meaningfully
applied to genomes.
You can represent the genome in some other way, in which case
there is an information content to your model ... but it
depends what you mean by information when you talk about the
information content of a genome.
If you use any concept of meaning in the definition of information
it cannot apply to genomes any more than it can apply to a
jello-mold.
I think most creationists use a 'meaning' oriented definition
of information, whereas most engineering research focusses on the
'data' underlying that information.
My opinion is that the reason all attempts to apply Info.Theory
to genomes is flawed is that the 'information' is an emergent
property of the chemical reactions within the cell -- that is
the information is at the organismic level -- even that view is
tenuous and not useful since without an intelligent interpreter
there is no information at all.

This message is a reply to:
 Message 16 by NosyNed, posted 10-28-2003 2:23 PM NosyNed has replied

Replies to this message:
 Message 18 by NosyNed, posted 10-29-2003 10:50 AM Peter has replied
 Message 19 by NosyNed, posted 10-29-2003 10:50 AM Peter has seen this message but not replied
 Message 20 by Loudmouth, posted 10-29-2003 12:15 PM Peter has replied

  
NosyNed
Member
Posts: 9004
From: Canada
Joined: 04-04-2003


Message 18 of 23 (63305)
10-29-2003 10:50 AM
Reply to: Message 17 by Peter
10-29-2003 3:35 AM


Ok, we agree. However, this just makes clear that we can not use the word "information" all by itself. There is Shannon information, semantic information and who knows what else.
Without being clear what we are talking about there is no good trying to discuss the issues.

This message is a reply to:
 Message 17 by Peter, posted 10-29-2003 3:35 AM Peter has replied

Replies to this message:
 Message 22 by Peter, posted 10-30-2003 4:56 AM NosyNed has not replied

  
NosyNed
Member
Posts: 9004
From: Canada
Joined: 04-04-2003


Message 19 of 23 (63306)
10-29-2003 10:50 AM
Reply to: Message 17 by Peter
10-29-2003 3:35 AM


Ok, we agree. However, this just makes clear that we can not use the word "information" all by itself. There is Shannon information, semantic information and who knows what else.
Without being clear what we are talking about there is no good trying to discuss the issues.

This message is a reply to:
 Message 17 by Peter, posted 10-29-2003 3:35 AM Peter has seen this message but not replied

  
Loudmouth
Inactive Member


Message 20 of 23 (63312)
10-29-2003 12:15 PM
Reply to: Message 17 by Peter
10-29-2003 3:35 AM


That's a different matter -- all I was (and have elsewhere) said
is that Shannon's information theorem cannot be meaningfully
applied to genomes.
I also got the idea that informatin entropy also doesn't apply, refuting the idea of "no new information" in the genome.

This message is a reply to:
 Message 17 by Peter, posted 10-29-2003 3:35 AM Peter has replied

Replies to this message:
 Message 23 by Peter, posted 10-30-2003 4:58 AM Loudmouth has not replied

  
Loudmouth
Inactive Member


Message 21 of 23 (63313)
10-29-2003 12:24 PM
Reply to: Message 1 by NosyNed
10-26-2003 12:52 PM


I was reading the Internet Infidels site and came across this post from Coragyps:
Another reference to "which mutation was the decrease in information":
"Conversion of a Peroxiredoxin into a Disulfide Reductase by a Triplet Repeat Expansion", Daniel Ritz, Jackie Lim, C. Michael Reynolds, Leslie B. Poole, and Jon Beckwith, Science 2001 October 5; 294: 158-160.
quote:
Pathways for the reduction of protein disulfide bonds are found in all organisms and are required for the reductive recycling of certain enzymes including the essential protein ribonucleotide reductase. An Escherichia coli strain that lacks both thioredoxin reductase and glutathione reductase grows extremely poorly. Here, we show that a mutation occurring at high frequencies in the gene ahpC, encoding a peroxiredoxin, restores normal growth to this strain. This mutation is the result of a reversible expansion of a triplet nucleotide repeat sequence, leading to the addition of one amino acid that converts the AhpC protein from a peroxidase to a disulfide reductase. The ready mutational interconversion between the two activities could provide an evolutionary advantage to E. coli.
So, something can be complex and have different specificities, all tied into a specific mutation. I am thinking that an IDer would have a tough time pointing to the "information loss" in this dichotomy, i.e. both enzymes from the different alleles of the AhpC gene are specific, just not to the same substrate.
Link to the Internet Infidels evolutin forum for those who want to search for the original post.

This message is a reply to:
 Message 1 by NosyNed, posted 10-26-2003 12:52 PM NosyNed has not replied

  
Peter
Member (Idle past 1510 days)
Posts: 2161
From: Cambridgeshire, UK.
Joined: 02-05-2002


Message 22 of 23 (63439)
10-30-2003 4:56 AM
Reply to: Message 18 by NosyNed
10-29-2003 10:50 AM


Yes.

This message is a reply to:
 Message 18 by NosyNed, posted 10-29-2003 10:50 AM NosyNed has not replied

  
Peter
Member (Idle past 1510 days)
Posts: 2161
From: Cambridgeshire, UK.
Joined: 02-05-2002


Message 23 of 23 (63440)
10-30-2003 4:58 AM
Reply to: Message 20 by Loudmouth
10-29-2003 12:15 PM


I agree with that too.

This message is a reply to:
 Message 20 by Loudmouth, posted 10-29-2003 12:15 PM Loudmouth has not replied

  
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