If the TOE is correct then it would be unfathomable to believe that insignificant lifeforms on an insignificant planet in an insignificant galaxy could ever grasp the most minute iota of understanding of such complex concepts as time and space and all the ridiculously complex thought systems that man has a grasp on. That kind of higher thought, found only in humans only serves to undermine and negate the validity of the TOE.
But, if it must be discussed, the only explanation I need for man to possess such knowledge is his consumption of fruit from the Tree of Knowledge of Good and Evil, sometimes referred to as the Tree of Conscience. God said, "The man has now become like one of us, knowing good and evil. He must not be allowed to reach out his hand and take also from the tree of life and eat, and live forever."
We should leave space and time to the one who didn't merely create it, but is actually the very essence of it. Only God knows when time started and when it ends because He is already there; "I am the Alpha and the Omega, the First and the Last, the Beginning and the End."
What we humans should then focus our energies on is what we are going to do with the time God has given us. It matters less where we came from and much more where humanity is going.