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Author Topic:   Morphology and mutation
Wounded King
Member
Posts: 4149
From: Cincinnati, Ohio, USA
Joined: 04-09-2003


Message 1 of 4 (51781)
08-22-2003 7:34 AM


A previous thread on mutations leading to structural changes in an organism seems to have dropped off the end of this Forum. I was going to add this particular example to it.
Trends Genet. 2003 May;19(5):248-52.
The callipyge locus: evidence for the trans interaction of reciprocally imprinted genes.
Georges M, Charlier C, Cockett N.
The callipyge phenotype in sheep is an inherited muscular hypertrophy that affects only heterozygous individuals who receive the CLPG mutation from their father. The CLPG mutation is a single nucleotide substitution in what is probably a long-range control element (LRCE) within the DLK1-GTL2 imprinted domain. Recent results suggest that the unique mode of inheritance of callipyge, referred to as polar overdominance, results from the combination of the cis-effect of the CLPG mutation on the expression levels of genes in the DLK1-GTL2 imprinted domain, and the trans interaction between the products of reciprocally imprinted genes.
this paper is also interesting in that the mutation is regulated by imprinting and shows that epigenetic factors can have considerable influence on phenotype.

Replies to this message:
 Message 2 by Adminnemooseus, posted 08-22-2003 11:54 AM Wounded King has replied

Adminnemooseus
Administrator
Posts: 3976
Joined: 09-26-2002


Message 2 of 4 (51827)
08-22-2003 11:54 AM
Reply to: Message 1 by Wounded King
08-22-2003 7:34 AM


Lost topic
My guess is that you're looking for "Mutations & structural modifications - Redux" - Most recent message 6/6/03.
You need to go to the "Show last __ topics" box, at the upper right corner of the index page, choose a number higher than what your default is, and reload the page. That will give you a list that goes further back. Also, that default number can be changed to a higher number in your "preferences".
Another alternative would be to click on your name, and get the list of the 20 most recent topics that you have posted to. That, however, would not have helped in this instance.
Or, you may wish to consult the database I have referenced at "All Topic database available".
I haven't reviewed the above mentioned topic, but I suspect that message 1 of this topic should be transplanted to there, and this topic be closed.
Adminnemooseus
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This message is a reply to:
 Message 1 by Wounded King, posted 08-22-2003 7:34 AM Wounded King has replied

Replies to this message:
 Message 3 by Wounded King, posted 08-22-2003 12:04 PM Adminnemooseus has replied

Wounded King
Member
Posts: 4149
From: Cincinnati, Ohio, USA
Joined: 04-09-2003


Message 3 of 4 (51833)
08-22-2003 12:04 PM
Reply to: Message 2 by Adminnemooseus
08-22-2003 11:54 AM


Sounds good to me, I didn't realise it was a result of my set-up, doops!

This message is a reply to:
 Message 2 by Adminnemooseus, posted 08-22-2003 11:54 AM Adminnemooseus has replied

Replies to this message:
 Message 4 by Adminnemooseus, posted 08-23-2003 8:00 PM Wounded King has not replied

Adminnemooseus
Administrator
Posts: 3976
Joined: 09-26-2002


Message 4 of 4 (52001)
08-23-2003 8:00 PM
Reply to: Message 3 by Wounded King
08-22-2003 12:04 PM


Moved message 1, topic closing down
I have moved the content of message 1, to the other above mentioned topic. This one is now closed.
Adminnemooseus
------------------
Comments on moderation procedures? - Go to
Change in Moderation?
or
too fast closure of threads

This message is a reply to:
 Message 3 by Wounded King, posted 08-22-2003 12:04 PM Wounded King has not replied

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