This is just an idea that i'm trying to expand on currently through my research at the university. I have always had the idea that instead of the progression of the human genome into some more genetically sophisticated being, humans are experiencing genetic degredation resulting in the more prominent diseases of heredity which we are seeing more and more of in this day than ever before.
Possible mechanisms of this degredation could be a bottle neck that may have happened in our ancient history. This would cause less diversity within the genome, thus, promoting imbreeding. I also think that it is a possibility that random genetic drift may have much more of an impact on our species than most think. In many areas we can classify numbers of subpopulations that have a great chance of fixation of deletarious alleles, especially in the poorer areas where people tend to live their entire lives within a distinct geographic location and interbreed with other people native to that area.
I have witnessed this first hand traveling through the impoverished areas of the midwest where famillel disorders are common.
Maybe this is happening on a greater, yet much slower scale, world-wide.
Anyway, i think this is an interesting alternative view to the thought that man is evolving through forward progression into some more advanced and better fit, being.