quote:
Originally posted by Matt:
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Originally posted by Luis_H:
Darwin's theory has helped us so much. Especially in medical science. I don't where we, as a human race, would be if the theory of natural selection hadn't been applied to medicine.
Please explain to all of us where "evolution" has anything to do with medical science. I would really like to know.
I just couldn't resist. Let me give you something to research a bit while I'm traveling for the next week or so:
1. Eukaryote mitochondria contains ribosomes that are totally different from ribosomes in the rest of the cell.
2. Mitochondrial ribosmes show sequence homology with bacterial ribosomes (specifically,
Rikettsia).
3. Evolutionary theory explaining this fact, specifically serial endosymbiosis theory (SET), states that around a billion or so years ago mitochondria were free-living bacteria that were internalized by other prokaryotes.
If mitochondrial ribosomes are in fact related to bacterial ribosomes, this has significant implications for medicine, as antibacterial drugs that operate by inhibiting bacterial ribosomes would effect normal cellular ribosomes the same way.
As an example:
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Chloramphenicol blocks protein synthesis by bacterial and most mitochondrial ribosomes, but not by cytoplasmic ribosomes. Conversely, cyclohexamide inhibits protein synthesis by eukaryotic cytolasmic ribosomes but does not affect protein synthesis by mitochondrial ribosomes or bacterial ribosomes. (Lodish, Molecular Cell Biology, 3d ed.)
Using evolutionary theory, researchers can design drugs that target bacteria, but that don't ALSO target our own mitochondria. Without knowledge of evolution, a drug that kills bacteria could as easily kill us by interfering with our own mitochondria!
See you in a week.