Shhhh, Mark, you'll give it away.
I know all about PB's continual referral to "non-random mutations". I'm merely trying to figure out a way of phrasing the question where he has no choice but to give an example. As far as hotspots go, all they are is a statistical "figure of speech" as it were - as I've argued with him before. I'm basically trying to get him to focus on a modern example that can definitively be attributed to non-randomness and how that can be distinguished from random. After all, if PB (and now Williams, apparently) are so all-fired sure that non-random mutations exist, they ought to be able to use that to predict
something that would be different from random chance, beyond a mere statistical fluke.
I agree on the ancestral bits, although I think it's possible to show rapidly evolving, non-conserved sequences between closely related organisms. Of course, that requires an
a priori acceptance that the two organisms ARE related by common descent... Which, I guess, is the point.
I know PB probably won't respond beyond re-asserting what he's already stated. However, maybe Williams is different ("hope oft springs eternal", or words to that effect).