Does the Darwinian theory require modification or replacement?

Seems your a little mixed up or you answer before you know the facts.Mae-wan Ho, presented this paper, which is a review of the many papers she published with P.T. Saunders on epigenetics,At a conference in re the future of evolution in Belgrade in 2009
Below are the presenters at the conference.Are they all woo's?AbstractsName Abstracts
Prof. Gnther Altner Evolution and CreationProf. Francisco J. Ayala On the Origins of Modern Science:
Copernicus and DarwinProf. David Cooper Evolution, Environment, and BeautyProf. Deniel Dennett Darwin’s "Strange Inversion of Reasoning"Prof. Eve-Marie Engels Charles Darwin's Conception of Morality and
Today's Evolutionary EthicsProf. Mikhail N. Epstein
Genocentrism of R. Dawkins and the Personalist
Argument for the Existence of GodProf. Hille Haker The Responsible Self - Questions after DarwinProf. John Harris Evolution: the Enhancement PhaseDr. Mae Wan Ho
Development and Evolution RevisitedProf. Otfried Hoeffe Homo sapiens: An animal morabileProf. Felix T. Hong Cognitive Darwinism: Deciphering the Enigma of
Human CreativityDr. Philippe Huneman Investigating Current Cooperation Studies in
Evolutionary Theory: Philosophy of Science and
the Prospects for a Unified Biological
Understanding of Human AltruismProf. Eva Jablonka Soft Inheritance in the 21st CenturyProf. Gorazd Kocijancic Time and Hypostasis- On Evolution as a
"Transcendental Illusion"Prof. Nikolaus Knoepffler Enhancement — and Escalation Model for an
Ethical EvaluationProf. Radoje Lausevic Climate Change, Altruistic Behavior and MoralityProf. Michael Leslie DNA and the Evolution of Motifs in Beethoven’s
Greatest Piano Work The Hammerklavier Sonata"Prof. Dietmar Mieth The Evolution and the Question of God and Moral.
The Example of the Discussion about Richard
Dawkinspage 2 >>AbstractsName Abstracts
Dr. Jurgen Neffe DarwinProf. Hilary Rose Celebrating Darwin’s Birthday — a Problematic
Inheritance?Prof. Steven P. Rose From Dobzhansky’s Dictum to Developmental
Systems TheoryProf. Peter Saunders What can Development tell us about Evolution?Prof. Neven Sesardic Heredity, Environment and EqualityDr. Stefan Lorenz Sorgner Evolution, Education, and Genetic EnhancementDr. Predrag Sustar What is Natural Selection? A Tip from Cancer
ResearchProf. Emer. Armin Tenner Future and EnergyProf. Peter Weish Evolution and EthicsProf. Ernst Ulrich von Weizsacker Darwinism Comprehended as a Permission To Be
"weak"

I am discussing Ho.
Ho is a nutbag.Provide evidence of directed evolution in higher organisms.
Or admit defeat.

I am reading the paper and her prior papers and will post later on them.You should read her papers and then let me know if she is a "nutbag."It's not about winning or losing, but looking at new ideas in evolution, and possibly acdepting new ideas.
If anyone is interested in the Belgrade Conference in 2009 you can find it here,
http://www.evolution.konras.com

Here's a pubmed search of Mae-wan Ho.Care to show me the "many" papers on epigenetics?

Papers published in the research literature I hope.
I provided a pubmed search in my prior post in case you need a little help finding them. I read plenty of this woman's addled rambling yesterday. Here's a taste: Ooooooooo!

I quit smoking that stuff before I even got accepted to grad school. A long time ago......

I suppose I could do that, but I'm not sure I need to yet."Purifying selection" is not some random term that Shapiro coined. The term has a standard meaning. You can look it up on Wikipedia or find it defined in scientist papers.From Widespread purifying selection at polymorphic sites in human protein-coding loci, Austin L. Hughes et alia.Widespread purifying selection at polymorphic sites in human protein-coding loci - PMC

quote:

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One feature that can be indicative of the deleterious consequences of a given allele is evidence of purifying selection (13). Purifying selection is the form of natural selection that acts to eliminate selectively deleterious mutations.

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From WikipediaNegative selection - Wikipedia(natural_selection)

quote:

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In natural selection, negative selection[1] or purifying selection is the selective removal of alleles that are deleterious. This can result in stabilizing selection through the purging of deleterious variations that arise.

​

Purging of deleterious alleles can be achieved on the population genetics level, with as little as a single point mutation being the unit of selection. In such a case, carriers of the harmful point mutation have fewer offspring each generation, reducing the frequency of the mutation in the gene pool.

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Wouldn't Shapiro have defined "purifying selection" if he was not using the term in its ordinary sense?

We're talking Rupert Sheldrake levels of delusion here. Morphogenic fields, biophotons, etc. Take a look at the talk she gave for the Radionic Association.Just a taste. What's "radionics"? So glad you asked. The woo is strong with this one.

Does she make any sense here or is this just woo?

No, claiming that "There is decidedly no homology of genes corresponding to homology of biological structures." means instead that she is talking nonsense.There is certainly no universal expectation of conservation of function, it is easily shown that developmental pathways can be modified to different endpoints and triggers. However there is a wealth of data showing substantially conserved homologies of function and genetic networks across species and indeed across phyla.TTFN,WK

Are you going to cite a PAPER published in the RESEARCH LITERATURE or not?Either cite a PAPER or withdraw your claim of directed mutation in higher organisms.

Stress-induced variation in evolution: from behavioural plasticity to genetic assimilation
Alexander V Badyaev*
+ Author AffiliationsDepartment of Ecology and Evolutionary Biology, University of Arizona Tucson, AZ 85721-0088, USA
. (abadyaev@email.arizona.edu)
Abstract
Extreme environments are closely associated with phenotypic evolution, yet the mechanisms behind this relationship are poorly understood. Several themes and approaches in recent studies significantly further our understanding of the importance that stress-induced variation plays in evolution. First, stressful environments modify (and often reduce) the integration of neuroendocrinological, morphological and behavioural regulatory systems. Second, such reduced integration and subsequent accommodation of stress-induced variation by developmental systems enables organismal ‘memory’ of a stressful event as well as phenotypic and genetic assimilation of the response to a stressor. Third, in complex functional systems, a stress-induced increase in phenotypic and genetic variance is often directional, channelled by existing ontogenetic pathways. This accounts for similarity among individuals in stress-induced changes and thus significantly facilitates the rate of adaptive evolution. Fourth, accumulation of phenotypically neutral genetic variation might be a common property of locally adapted and complex organismal systems, and extreme environments facilitate the phenotypic expression of this variance. Finally, stress-induced effects and stress-resistance strategies often persist for several generations through maternal, ecological and cultural inheritance. These transgenerational effects, along with both the complexity of developmental systems and stressor recurrence, might facilitate genetic assimilation of stress-induced effects. Accumulation of phenotypically neutral genetic variance by developmental systems and phenotypic accommodation of stress-induced effects, together with the inheritance of stress-induced modifications, ensure the evolutionary persistence of stress—response strategies and provide a link between individual adaptability and evolutionary adaptation.

And where does Badyaev discuss directed mutation? Directed evolution?

Shadow71,Can you indicate, in your own words, how this paper supports your argument? I could make some guesses about the Ho paper, but this Badyaev paper covers a lot of ground.

Just a quick note, NN.
That is a talk Ho gave, not a paper.
Shadow has yet to quote Ho's published work.