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Author Topic:   Molecular Population Genetics and Diversity through Mutation
Dr Adequate
Member (Idle past 315 days)
Posts: 16113
Joined: 07-20-2006


Message 273 of 455 (785777)
06-10-2016 12:45 PM
Reply to: Message 268 by Faith
06-10-2016 10:03 AM


Re: Situation
I just heard a talk about how Islam is going to run Europe and the UK within a decade and how all your leaders keep denying it, same as most of you all here. This reminds me of that. Wishfulness reigns. Couldn't resist the comparison.
I will grant you that the comparison is extremely apt.
So is this something I can persuade you to bet money on?
Edited by Dr Adequate, : No reason given.

This message is a reply to:
 Message 268 by Faith, posted 06-10-2016 10:03 AM Faith has not replied

  
Dr Adequate
Member (Idle past 315 days)
Posts: 16113
Joined: 07-20-2006


(2)
Message 277 of 455 (785792)
06-11-2016 10:35 AM
Reply to: Message 276 by Faith
06-11-2016 8:50 AM


Re: Situation
What I’ve said is that after you have an established breed you don’t WANT any more changes because they mess up the breed.
And it has been pointed out to you that the desires of breeders do not affect the operation of mutation and selection in the wild.
No, what I’ve said is that there is a TREND to genetic REDUCTION down any evolving line ...
And now that you admit that mutations exist and increase genetic diversity you cannot "prove" this by adducing the "fact" that they don't. So on what basis do you propose to establish it?
Let's remind you again. Two wolves:
Dogs:
The genetic diversity of Canis lupus has increased, has it not?

This message is a reply to:
 Message 276 by Faith, posted 06-11-2016 8:50 AM Faith has not replied

  
Dr Adequate
Member (Idle past 315 days)
Posts: 16113
Joined: 07-20-2006


(1)
Message 280 of 455 (785800)
06-11-2016 1:00 PM
Reply to: Message 279 by Faith
06-11-2016 12:33 PM


Re: Situation
If they make ordinary alleles they'll be reduced in the selective processes of forming a new breed or species anyway, and the result of those processes is always going to be reduced genetic diversity no matter what the source of the diversity in the first place;
Yes, selection decreases diversity. Mutation adds it. The question of whether in a given case net diversity has been decreased or increased is an empirical one.
If they get added after the species is formed they'll wreck the species or breed
You mean like all those dog breeds have "wrecked" C. lupus? And like all those different chihuahuas have "wrecked" the chihuahua breed?
Well, the laws of nature don't care whether you think genetic diversity is a good thing or a bad thing, they just go on adding genetic diversity regardless.

This message is a reply to:
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Dr Adequate
Member (Idle past 315 days)
Posts: 16113
Joined: 07-20-2006


Message 285 of 455 (785806)
06-11-2016 1:46 PM
Reply to: Message 281 by Faith
06-11-2016 1:04 PM


Re: Situation
l How they occurred in the first place is the question, but I'm not accepting standard mutations since most of them do nothing good.
Similarly, there are no winning lottery tickets because most of them lose. That's Creationist Logic.

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 Message 281 by Faith, posted 06-11-2016 1:04 PM Faith has not replied

  
Dr Adequate
Member (Idle past 315 days)
Posts: 16113
Joined: 07-20-2006


Message 291 of 455 (785814)
06-11-2016 2:50 PM
Reply to: Message 290 by Faith
06-11-2016 2:43 PM


Re: An allele by any other name
Actually, Faith, you don't get to redefine the English language on a whim.

This message is a reply to:
 Message 290 by Faith, posted 06-11-2016 2:43 PM Faith has replied

Replies to this message:
 Message 292 by Faith, posted 06-11-2016 2:54 PM Dr Adequate has replied

  
Dr Adequate
Member (Idle past 315 days)
Posts: 16113
Joined: 07-20-2006


Message 293 of 455 (785816)
06-11-2016 2:56 PM
Reply to: Message 292 by Faith
06-11-2016 2:54 PM


Re: An allele by any other name
The English language carries whole theories, you know, and I use it correctly to express the theory I hold.
Is it your theory that there are no deleterious alleles?

This message is a reply to:
 Message 292 by Faith, posted 06-11-2016 2:54 PM Faith has not replied

  
Dr Adequate
Member (Idle past 315 days)
Posts: 16113
Joined: 07-20-2006


Message 305 of 455 (785832)
06-11-2016 9:10 PM
Reply to: Message 302 by Faith
06-11-2016 7:11 PM


Re: Mutations are not alleles
And "neutral" mutations are killers of normal alleles. At least they set the stage for their complete killing when another mutation comes along. There is nothing benign about "neutral" mutations.
Well, there is something benign about them, namely their complete benignity.

This message is a reply to:
 Message 302 by Faith, posted 06-11-2016 7:11 PM Faith has not replied

  
Dr Adequate
Member (Idle past 315 days)
Posts: 16113
Joined: 07-20-2006


Message 306 of 455 (785834)
06-11-2016 9:14 PM
Reply to: Message 301 by Faith
06-11-2016 7:08 PM


Re: An allele by any other name
Wonderful. No difference between disease and health, no difference between healthy genetic diversity needed by the genetically impoverished seals and some kind of useless mutational diversity. This is science?
There is a difference, but it is not expressed by using the word "allele" only for beneficial alleles and some other word for the rest.
That is not how the English language works, Faith. Instead, we modify nouns with adjectives in order to describe their qualities. So for example we speak of beneficial alleles and deleterious alleles.
HE WAS REFERRING TO PHENOTYPIC DIVERSITY WHICH MAKES HASH OUT OF MY ARGUMENT WHICH IS ALL ABOUT GENETIC DIVERSITY.
As I pointed out, the phenotypic diversity results from genetic diversity. For example, the reason that those chihuahuas have different coat colors is that they have different alleles for coat color.
All the more hopeless since I found out that polymorphic genes seem to be predominantly disease-causers ...
You should really learn to distinguish between things you find out and things you make up.
Why you can't see it is the puzzle.
Because we do not live in the insane fantasy-land that exists in your demented little head, Faith.
Edited by Dr Adequate, : No reason given.

This message is a reply to:
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Dr Adequate
Member (Idle past 315 days)
Posts: 16113
Joined: 07-20-2006


Message 315 of 455 (785856)
06-12-2016 12:19 PM
Reply to: Message 312 by Faith
06-12-2016 6:57 AM


Re: Mutations are not alleles
Then there was that Wikipedia article that pretty much defined polymorphic genes as disease-causers.
You goddamned liar.
Trusting you guys in a sense, not realizing that you don't distinguish between disease-causing alleles and normal variants.
You goddamned liar.
In fact as I think about it now ALL mutations of alleles create polymorphic genes. That's what the mutations DO to alleles. Sort of flabbergasting that I hadn't put all that together before.
Well, if this was coherent it might actually be true. Mutations cause alleles; a polymorphic gene is by definition one with more than one allele. Since this is true by definition, it would indeed be flabbergasting if you'd only just realized this.
Edited by Dr Adequate, : No reason given.

This message is a reply to:
 Message 312 by Faith, posted 06-12-2016 6:57 AM Faith has not replied

Replies to this message:
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Dr Adequate
Member (Idle past 315 days)
Posts: 16113
Joined: 07-20-2006


(1)
Message 319 of 455 (785925)
06-13-2016 2:24 PM
Reply to: Message 318 by Faith
06-13-2016 2:08 PM


Re: Mutations are not alleles
The Wikipedia article concerned ONLY disease processes, why is that?
It doesn't, as you admit later in the same paragraph.
Defining a disease allele as an allele is what is dishonest even if every geneticist does it. All it proves is that the ToE has a stranglehold on you all.
Faith. This is how the English language works. Nouns are modified by adjectives. We do not have one word for a red boat, and another for a blue boat. Instead we qualify the word "boat" by the words "blue" or "red", as the case may be. We do not have one word for a broken hairdryer and another word for a functioning hairdryer. Rather, we speak of "a broken hairdryer" and "a functioning hairdryer" respectively. And instead of having three different nouns for beneficial alleles, neutral alleles, and deleterious alleles, we speak of "beneficial alleles", "neutral alleles", and "deleterious alleles".
You may think that this is dishonest, Faith, but given that the English language has in current usage about 80,000 nouns and 40,000 adjectives, if we did things your way the English language would have to have a vocabulary consisting of over three billion words, which would make it insuperably difficult to learn.

This message is a reply to:
 Message 318 by Faith, posted 06-13-2016 2:08 PM Faith has replied

Replies to this message:
 Message 328 by Faith, posted 06-13-2016 4:11 PM Dr Adequate has replied

  
Dr Adequate
Member (Idle past 315 days)
Posts: 16113
Joined: 07-20-2006


Message 325 of 455 (785935)
06-13-2016 3:14 PM
Reply to: Message 324 by Taq
06-13-2016 3:09 PM


Re: Mutations are not alleles
Then why don't you help us out. We start with Population A, which has a DNA sequence of "AAAAAAAAA" at a specific point in their genome for all members of the population.
A new river forms and it splits the population in two. Since the species can't swim that well, there is no interbreeding between the pouplations. We call them Population B and Population C (or PB and PC for short).
In PB, a mutation occurs in the genetic locus, resulting in the sequence "AAAATAAAA". This mutation is selected for, and it replaces the old allele. The same mutation is not selected for in PC.
We now have two populations with a different allele at the same orthologous position.
PB= AAAATAAAA
PC= AAAAAAAAA
Now, would you define this as a loss in genetic diversity?
Oh, that's easy. In the Faith Theory Of Evolution And Not Reading Good, the only bit that counts is the bit highlighted in red, which is a loss of genetic diversity. The other stuff is irrelevant, as is the fact that genetic diversity has increased.

This message is a reply to:
 Message 324 by Taq, posted 06-13-2016 3:09 PM Taq has replied

Replies to this message:
 Message 326 by Taq, posted 06-13-2016 3:29 PM Dr Adequate has not replied
 Message 329 by Faith, posted 06-13-2016 4:12 PM Dr Adequate has replied

  
Dr Adequate
Member (Idle past 315 days)
Posts: 16113
Joined: 07-20-2006


Message 333 of 455 (785956)
06-13-2016 5:23 PM
Reply to: Message 328 by Faith
06-13-2016 4:11 PM


Re: Mutations are not alleles
THe point, which you have clearly managed to overlook or intentionally garble, is that the adjectives are not used ...
Yes they are. For example, if I want to say that an allele is deleterious, I use the adjective "deleterious". If I want to say that an allele is beneficial, I use the adjective "beneficial".
while the word "allele" is used alone to designate every sequence found at a gene locus
Yes. This is how nouns work. In the same way, though we can speak of "a red boat" or "a blue boat", the word "boats" is used alone to designate every boat.
This is how the English language works, Faith.
Edited by Dr Adequate, : No reason given.

This message is a reply to:
 Message 328 by Faith, posted 06-13-2016 4:11 PM Faith has not replied

  
Dr Adequate
Member (Idle past 315 days)
Posts: 16113
Joined: 07-20-2006


Message 334 of 455 (785957)
06-13-2016 5:26 PM
Reply to: Message 329 by Faith
06-13-2016 4:12 PM


Re: Mutations are not alleles
Perfect misrepresentation of my argument.
If that is not in fact your argument, then all the words you have spent on expounding that point of view would seem to have been wasted.

This message is a reply to:
 Message 329 by Faith, posted 06-13-2016 4:12 PM Faith has not replied

  
Dr Adequate
Member (Idle past 315 days)
Posts: 16113
Joined: 07-20-2006


(1)
Message 354 of 455 (786025)
06-14-2016 9:06 PM
Reply to: Message 353 by Faith
06-14-2016 8:57 PM


Re: Mutations are not alleles
Yes, we understand that you're "focused on" certain biological process, while completely ignoring others. This is what makes your argument so stupid.
You: All birds are flightless.
Us: What about owls and robins and finches and hummingbirds and ...
You: I'm not focusing on those. I'm focusing on ostriches and kiwis.
Us: But the other birds exist whether or not you "focus on" them.
You: Also evolutionary processes must inevitably reduce genetic diversity until evolution grinds to a halt.
Us: What about mutations?
You: I'm not focusing on that.

This message is a reply to:
 Message 353 by Faith, posted 06-14-2016 8:57 PM Faith has replied

Replies to this message:
 Message 355 by Faith, posted 06-14-2016 9:14 PM Dr Adequate has replied

  
Dr Adequate
Member (Idle past 315 days)
Posts: 16113
Joined: 07-20-2006


(1)
Message 358 of 455 (786029)
06-14-2016 9:49 PM
Reply to: Message 355 by Faith
06-14-2016 9:14 PM


Re: Mutations are not alleles
Aren't you supposed to be a genius? You are certainly obtuse for a genius. The mutations don't count because they would only function as normal alleles anyway, which I'm arguing have to be reduced in the formation of a new species or breed. It's the reduction of the genetic material, whether that material is made up of mutations or built-in alleles, that is the point. Mutations can not change the fact that to get a new species REQUIRES reduction of genetic diversity. You have to LOSE them to get a new species or breed, you HAVE to, Adding anything at this point is redundant or destructive.
So, you're not "focusing on" the bit where diversity is added.
Yeah, my point.
But I know I'm talking to a box of rocks. This has been explained at least a hundred times and you continue to have your obtuse silly straw man you made up yourself without ever getting for half a second what I'm talking about. Then you have the gall to call me names.
Again, we are familiar with your desperate, impotent attempts to evade reality, and we understand them perfectly. We are merely unconvinced.

This message is a reply to:
 Message 355 by Faith, posted 06-14-2016 9:14 PM Faith has replied

Replies to this message:
 Message 359 by Faith, posted 06-14-2016 9:56 PM Dr Adequate has replied

  
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