One interesting feature of vertebrate genomes is the presence of quite large stretches of
highly conserved non-coding DNA. Not only are these regions non-coding but there is no evidence that they are transcribed as might be the case if they contained microRNA operons.
Exactly how these stretches act to regulate gene expression is unclear but they provide a fertile substrate for the generation of distinct expression patterns by very small changes in the genome.
TTFN,
WK