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Member (Idle past 6644 days) Posts: 224 From: Stroud, OK USA Joined: |
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Author | Topic: Quality Control the Gold Standard | |||||||||||||||||||||||||||
Evopeach Member (Idle past 6644 days) Posts: 224 From: Stroud, OK USA Joined: |
If you will read carefully I said the error rate in copying once the entire human genome according to the best literature is 1 base pair error in the new copy per billion base pairs.
Admittedly there are other sources of mutation., etc. but I was talking about the inherent rate which is unavoidable according to the latest research. In Six Sigma parlance it is the "process capability" and will occur. Mutation in total includes mutagens, radiation induced, environmentals etc. and are perhaps avoidable. My point stands. Errors due to the inherent limitations on DNA copying mechanism accuracy is 1 in 10**9 th base pairs.
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Evopeach Member (Idle past 6644 days) Posts: 224 From: Stroud, OK USA Joined: |
SO you think the comparision of the publics k-12 exposure to relativity theory and quantum mechanics is commensurate with their exposure to all things evolutionary.
Your post is a prime example of distortion, inuendo, half-truths and illogical argument. The public from age 3 to 30 is pillaried with evolutionary dogma from every avenue in American life. I guess I missed the three movies on Jarassic QUARK I II III. If your argument is Americans are too ingorant and stupid to understand the brilliance of the evolutionary bioloby crowd.. just say it in plain english. How about, we listened to this evolution stuff for 25 years and it doen't make common sense, fit with other requirements of scientific theory and the proponents are the most arrogant egocentric people in the country.
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Evopeach Member (Idle past 6644 days) Posts: 224 From: Stroud, OK USA Joined: |
If you think my example of a seven sigma operation strictly observable in every science lab so equipped, the copying of the DNA molecule, is erroneous I simply refer you to the Human Genome Project material releaased.
Changes in the DNA code are called mutations. Repair enzymes repair most of the errors that occur in DNA.http://faculty.clintoncc.suny.edu/...%20Lectures/DNA/dna.htm Errors During DNA Replication One in 100,000 bases are mismatched. Several enzymes including DNA polymerase proofread and remove mismatched bases. Mismatching causes replication to pause while the mismatch is removed and replaced with the correct nucleotide. After proofreading, the error rate is 1 in 1 billion base pairs. If you think 1 in a billion is not seven sigma for a normal distribution then thats your problem.
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Evopeach Member (Idle past 6644 days) Posts: 224 From: Stroud, OK USA Joined: |
PLease dont post to me anymore.. I have no interest in discussing with totally intellectually dishonest people.
There are maybe 1% of all high schools who broach the subject of QM or relativity ....yet every book store has books about dinos and their ages and cave men starting with pre-school. Every HS has an evolutionary based Bioloy class (es). You are a very dishonest person.. period.
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Evopeach Member (Idle past 6644 days) Posts: 224 From: Stroud, OK USA Joined: |
You are not paying attention.
I agree the overall mutation rate is higher when every source is considered. That does not change the fact that the DNA molecule is routinely replicated with only three base pair errors per billion. That is mathmatically a seven sigma level of accuracy. Its not debateable.. its a 100% true fact... period.
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Evopeach Member (Idle past 6644 days) Posts: 224 From: Stroud, OK USA Joined: |
Main Entry: av·e·nue
Pronunciation: 'a-v&-"n, -"ny Function: noun Etymology: Middle French, from feminine of avenu, past participle of avenir to come to, from Latin advenire -- more at ADVENTURE 1 : a way of access : ROUTE Accessing the public mind for instance. Your post is a list of ACTIVITIES not avenues. Precision in thought and word is quite important really... try harder. Movies are an avenue of education and cultural change as is all state screen and sound. As in Jarassic Park.. not Quark. As in the hundreds of computer games, books and media forms presenting dinosaurs and cave men etc. and all things evolutionary. Sorry no books for my grandkids on QM or Relativity. See evolutionary theory is so non-mathmatical, so soft and squishey, no qualitative and plastic that people with no scientific training at all can be indoctrinated with out understanding tensor analysis or partial differential equations. So every level of education from pre-school through college teaches science that assumes evolution is true and proven beyond any reasonable doubt. As to bad evolution being taught to people by creationists just where is that happening on anything other than a small scale.. certainly not in public schools, nor parochial schools nor in any collge at all. Certainly not on TV documentaries, NOVA, sci-fi, A&E, NPR or any other outlet... that's 99.999% evolutionary based programming where science is concerned... period. Those bad biology books and such are written by evos and reviewed by evos .. if the're bad its your problem.
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Evopeach Member (Idle past 6644 days) Posts: 224 From: Stroud, OK USA Joined: |
No I'm looking at the Human Genome literature and a book published called exons entrons and ... which documents the results and history of same and about a dozen papers on the subject via google.
I am also looking at the net error rate after all repair mechanisms in the cell have performed their work. If you can't read .. thats your problem.
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Evopeach Member (Idle past 6644 days) Posts: 224 From: Stroud, OK USA Joined: |
I would be interested in the paper if I had the reference.
Of course starting with rna de novo casts a long shadow as I suggest we can harly believe rna emerged by chance... its harly simple or crude.. just not up to the task it is asked to perform. Was the experiment carried out in a primal environment or a very designed, protected and cultured one. If the latter were such conditions available in some pre-biotic setting to permit all those generations.. etc. Still being the open minded type I'd like to read the details.
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Evopeach Member (Idle past 6644 days) Posts: 224 From: Stroud, OK USA Joined: |
So the rate that was measured or calculated from direct observations , etc. by the various scientific teams were just lucky. The rate they measured was by luck free of all other sources of error repeatedly so that their results wee only for one source and not the net effect of the cells operations including repair of many errors.. just not all.
How unfortunate that just by luck they were there when no other sources of error were occuring... many many times. Do you you still have your mouseketeer ears?
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Evopeach Member (Idle past 6644 days) Posts: 224 From: Stroud, OK USA Joined: |
I just refer you to the book exond entron and genes the history of the Human Genome project among others. It was not a table it was a rather detail analysis of the subject. You are boring me with your equivocations so just drop it.
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Evopeach Member (Idle past 6644 days) Posts: 224 From: Stroud, OK USA Joined: |
Yes he won the Nobel prize for taking a dead RNA section and putting into a nutrient environment of amino acids and seeing the dead RNA use the beitiens to make a virus that was alive in the sense that it could continue to replicate. All it needed was complete rna and the nutrients. Hmmm all it needed was rna.
Think about it.
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Evopeach Member (Idle past 6644 days) Posts: 224 From: Stroud, OK USA Joined: |
I suggest you fellows and gals read Origins by Shapiro very carefully and then come back.
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Evopeach Member (Idle past 6644 days) Posts: 224 From: Stroud, OK USA Joined: |
The phrase "under certain conditions", used above, must of course be made precise. The assumptions are (1) the sample size n is small by comparison to the size of the whole population, and (2) the population is in statistical equilibrium under mutation and genetic drift and the role of selection at the locus in question is negligible, and (3) every mutant allele is novel. (See also idealised population.)
WOW! I'll bet these assumptions are determinable every century or so. Of cource since selection is only determined after the fact of many generations it must be marvy to assume it. Like wise all novel mutations. LOL Lets see I just examined the undergrad bioloigy curriculum at five major public universities and just like last years review the math includes general math and stops at the sophmore year with Caluculs Inroduction for Non-math students. Funny I seem to recall my engineering track was Colleg ALg & Trig, four semester of Calculus, One semester of Diff. Eq. , one semester of Vector Analysis and Complex Variables. That help any?
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Evopeach Member (Idle past 6644 days) Posts: 224 From: Stroud, OK USA Joined: |
Again, the 10** -09 was always in the context of defining the inherent dna copying mechanism in the human cell over huge populations and long time periods as in the Genome Project.
You introduced all the other sources of mutation rates which are variant depending on a lot of variables that are difficult to isolate. The inherent "voice of the process" in base pair copying errors is Seven Sigma process in the human cell. Page not found | Schlick Group at NYU To replicate a single unit of human DNA, about 3 billion individual base pairs are joined. In the course of building a baby from a fertilized egg, this process goes on about a million billion times. Despite the seemingly infinite room for error, however, a mistake is made only once for every 10 billion operations. That means there's an impressive quality control system at work. One part of this DNA copying machine is the polymerase, a protein enzyme that ensures complementary bases are placed with one another as a strand of bases becomes duplicated DNA. Mechanisms that repair and ensure the fidelity of DNA as it is replicated are vital since many human diseases can originate from mutations that are the result of polymerase error. Keep posting I want to see if my ego meter can redline from your input alone.
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Evopeach Member (Idle past 6644 days) Posts: 224 From: Stroud, OK USA Joined: |
Funny I jest took a look at two Biology books one for HS and one for college Sophomores. In the front they list the editorial and peer review list and not one og thtem work for the publisher.
They do however work at major Universities, research groups, drug compoanies and governmental agenices like the FDA, AG, etc. And all but two had Phd's in biological sciences. Now talke your cr-- somewhere else peanut.
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