1. Adam and Eve had other children, and they had begun to populate an area called the land of Nod. I think this is plausible.
2. The Bible isn't factual. I disagree with this.
3. The Bible gives a hint at a deeper reality and structure within the universe, and that something had occurred resulting in a nearby land, called Nod, with people in it. Perhaps after the Fall, there was a change in the universe (multi-verse) that enabled people to emerge, sort of a blending of the time-line.
4. The people of the land of Nod were humanoid aliens. Just throwing this out for run.
Clearly, the authors state there was a land of Nod with people in it. They imply everyone stemmed from Adam and Eve and so that would make scenario 1 the most plausible intent of the author of Genesis.
But the Bible does not say. For all we know, the people of the land of Nod were the evos that evolved from apes which occurred after the Fall as time expanded, and they eventually intermingled with bad but also good creationists.