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Author Topic:   scientific end of evolution theory (2)
derwood
Member (Idle past 161 days)
Posts: 1457
Joined: 12-27-2001


Message 212 of 214 (19550)
10-10-2002 1:56 PM
Reply to: Message 5 by peter borger
07-09-2002 1:26 AM


quote:
Originally posted by peter borger:
A complete subdiscipline of phylogeny is concerned with reconsiliation of these trees through hypothetical additions and/or deletions of putative duplicated genes.

Pardon my language, but that is complete bullshit.


This message is a reply to:
 Message 5 by peter borger, posted 07-09-2002 1:26 AM peter borger has not yet responded

  
derwood
Member (Idle past 161 days)
Posts: 1457
Joined: 12-27-2001


Message 213 of 214 (19554)
10-10-2002 2:02 PM
Reply to: Message 5 by peter borger
07-09-2002 1:26 AM


quote:
Originally posted by peter borger:
I would like you to have a look at chromosome 2. Eight members of the IL-1 related genes are present in man’s chromosome 2, to be precise in location 2q11-2q14. Sequence comparison of the IL-1 related genes does not present evidence that a recent duplication of IL-1 beta took place in this region. On the contrary, the dendrogram of the IL-1 genes clearly demonstrates that the common ancestor copy of the IL-1 beta gene duplicated 3 times maximally, and gave rise to IL-1alpha (Smith, D.E. et al. Four new members expand the interleukin-1 superfamily Journal Biological Chemistry 2000, vol275, pp1169-1175

Hmmm...J Interferon Cytokine Res 2001 Nov;21(11):899-904

Identification of a novel human cytokine gene in the interleukin gene cluster on chromosome 2q12-14.

Bensen JT, Dawson PA, Mychaleckyj JC, Bowden DW.

Program in Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.

Genes in the interleukin-1 (IL-1) gene cluster on human chromosome 2 play an important role in mediating inflammatory responses and are associated with numerous diseases. We have identified a novel IL-1-like gene, IL-1F10, on human chromosome 2q13-14.1 near the IL-1 receptor antagonist gene (IL-1RN). The IL1F10 gene is encoded by 5 exons spanning over 7.8 kb of genomic DNA. The 1008-bp IL-1F10 cDNA encodes a 152-amino acid protein that shares between 41% and 43% amino acid identity with human IL-1 receptor antagonist (IL-1Ra) and FIL-1delta, respectively. IL-1F10 shares characteristics of the IL-1Ra family, including key amino acid consensus sequences and a similar genomic structure. By multitissue first-strand cDNA PCR analysis, IL-1F10 mRNA is expressed in heart, placenta, fetal liver, spleen, thymus, and tonsil. The expression in a variety of immune tissues and similarity to IL-1Ra suggest a role of IL-1F10 in the inflammatory response.


This message is a reply to:
 Message 5 by peter borger, posted 07-09-2002 1:26 AM peter borger has responded

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peter borger
Member (Idle past 5950 days)
Posts: 965
From: australia
Joined: 07-05-2002


Message 214 of 214 (19591)
10-10-2002 10:08 PM
Reply to: Message 213 by derwood
10-10-2002 2:02 PM


dear Dr Page,

I checked the human genome on IL-1 related genes (NCBI homepage, OMIM) and there are 8 members. The putative duplication still doesn't fit in. If it has been present than it gave rise to the IL-1 alpha. So the incongruence cannot be solved.

best wishes,
Peter


This message is a reply to:
 Message 213 by derwood, posted 10-10-2002 2:02 PM derwood has not yet responded

  
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