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Author Topic:   What have we accomplished?
PaulK
Member
Posts: 17828
Joined: 01-10-2003
Member Rating: 2.3


Message 147 of 263 (879305)
07-14-2020 12:37 PM
Reply to: Message 146 by Kleinman
07-14-2020 12:28 PM


Re: Self Serving Beliefs
quote:
So, in your vivid - and sick - imagination, you think you understand the mathematics of the Jukes-Cantor model.
I’ve proven that I understand it better than you, although that is a low bar, accomplished by reading a couple of web pages - both of which you’ve cited.
quote:
The Jukes-Cantor model is a time-dependent problem so it must have some initial condition. Tell us what that initial condition is and whether it is a scalar, vector, or matrix.
I really don’t have to jump through hoops for you.

This message is a reply to:
 Message 146 by Kleinman, posted 07-14-2020 12:28 PM Kleinman has replied

Replies to this message:
 Message 148 by Kleinman, posted 07-14-2020 1:26 PM PaulK has replied

PaulK
Member
Posts: 17828
Joined: 01-10-2003
Member Rating: 2.3


Message 149 of 263 (879309)
07-14-2020 1:35 PM
Reply to: Message 148 by Kleinman
07-14-2020 1:26 PM


Re: Self Serving Beliefs
quote:
You don't know! You don't understand the Jukes-Cantor model. You just like blowing smoke.
If that was true I wouldn’t be so successful in pointing out your grievous errors.

This message is a reply to:
 Message 148 by Kleinman, posted 07-14-2020 1:26 PM Kleinman has replied

Replies to this message:
 Message 150 by Kleinman, posted 07-14-2020 1:59 PM PaulK has replied

PaulK
Member
Posts: 17828
Joined: 01-10-2003
Member Rating: 2.3


Message 151 of 263 (879321)
07-14-2020 3:36 PM
Reply to: Message 150 by Kleinman
07-14-2020 1:59 PM


Re: Self Serving Beliefs
quote:
Don't do it for me, do it for your fellow fish-to-mammals aficionados.
You’re the one asking for it.
So, let’s see your understanding. Have you worked out why this claim is wrong yet?
The problem with the Markov Chain models given in the Wikipedia link above is that they are assuming the transition matrix is stationary...
( Message 94 )

This message is a reply to:
 Message 150 by Kleinman, posted 07-14-2020 1:59 PM Kleinman has replied

Replies to this message:
 Message 152 by Kleinman, posted 07-14-2020 3:47 PM PaulK has replied

PaulK
Member
Posts: 17828
Joined: 01-10-2003
Member Rating: 2.3


Message 153 of 263 (879325)
07-14-2020 4:12 PM
Reply to: Message 152 by Kleinman
07-14-2020 3:47 PM


Re: Self Serving Beliefs
quote:
You claim you understand the Jukes-Cantor model. You are a liar. You can't even tell us what the initial condition for that model is and whether it is a scalar, vector, or matrix. You just blow very stinky smoke
You certainly don’t let up on the projection. But you’re the one who claim to be the expert. I just claim that you don’t even know as much as I do.
quote:
What initial condition will give equilibrium in 1 replication (generation for a nitwit like you)?
Does this have anything to do with answering my question? If so you’ll have to explain the relevance. Because if you do understand your error rudely asking questions is a rather odd way to admit it.

This message is a reply to:
 Message 152 by Kleinman, posted 07-14-2020 3:47 PM Kleinman has replied

Replies to this message:
 Message 154 by Kleinman, posted 07-14-2020 4:24 PM PaulK has replied

PaulK
Member
Posts: 17828
Joined: 01-10-2003
Member Rating: 2.3


(1)
Message 155 of 263 (879328)
07-14-2020 4:33 PM
Reply to: Message 154 by Kleinman
07-14-2020 4:24 PM


Re: Self Serving Beliefs
quote:
I certainly know what the initial condition is for the Jukes-Cantor model and I know whether it is a scalar, vector, or matrix and you don't
But you don’t know what’s wrong with your claim. And you don’t even know why you asked:
What initial condition will give equilibrium in 1 replication (generation for a nitwit like you)?
quote:
You are a very stupid liar.
Do you really think that resorting to abuse will cover up your failures?

This message is a reply to:
 Message 154 by Kleinman, posted 07-14-2020 4:24 PM Kleinman has replied

Replies to this message:
 Message 156 by Kleinman, posted 07-14-2020 4:51 PM PaulK has replied

PaulK
Member
Posts: 17828
Joined: 01-10-2003
Member Rating: 2.3


Message 157 of 263 (879330)
07-14-2020 4:59 PM
Reply to: Message 156 by Kleinman
07-14-2020 4:51 PM


Re: Self Serving Beliefs
quote:
There is nothing wrong with my claim
Then you don’t understand Jukes-Cantor. What’s even worse is that I already explained the problem to you. And you still don’t understand it.
quote:
You are a very stupid liar.
Keep up with the pointless abuse. It just shows what a fraud you are.

This message is a reply to:
 Message 156 by Kleinman, posted 07-14-2020 4:51 PM Kleinman has replied

Replies to this message:
 Message 158 by Kleinman, posted 07-14-2020 5:14 PM PaulK has replied

PaulK
Member
Posts: 17828
Joined: 01-10-2003
Member Rating: 2.3


Message 159 of 263 (879334)
07-14-2020 5:19 PM
Reply to: Message 158 by Kleinman
07-14-2020 5:14 PM


Re: Self Serving Beliefs
Obviously all you can do is throw abuse.
You certainly can’t handle the math.

This message is a reply to:
 Message 158 by Kleinman, posted 07-14-2020 5:14 PM Kleinman has replied

Replies to this message:
 Message 160 by Kleinman, posted 07-14-2020 6:01 PM PaulK has replied

PaulK
Member
Posts: 17828
Joined: 01-10-2003
Member Rating: 2.3


Message 162 of 263 (879343)
07-14-2020 11:38 PM
Reply to: Message 160 by Kleinman
07-14-2020 6:01 PM


Re: Self Serving Beliefs
quote:
Whatever abuse I throw on you is nothing compared to the harm you fish-to-mammals aficionados cause with drug-resistant infections and failed cancer treatments.
So you tell worse lies. Big deal.
quote:
And you should tell the peer-reviewers, editors, publishers, and librarians at the National Library of Medicine where my papers can be found that I can't handle the math.
That would only be possible if they were your papers. The evidence of this thread - and the others you are participating in here - indicates that you aren’t capable of having written them.
But if you are capable of handling the math, if you aren’t just blowing smoke let’s discuss your corrections to Jukes-Cantor. And the problems you don’t see.
So, describe the form of your model. Do you model the changes to each base as a Markov chain as Jukes Cantor does?

This message is a reply to:
 Message 160 by Kleinman, posted 07-14-2020 6:01 PM Kleinman has replied

Replies to this message:
 Message 163 by Kleinman, posted 07-15-2020 3:35 AM PaulK has replied

PaulK
Member
Posts: 17828
Joined: 01-10-2003
Member Rating: 2.3


(1)
Message 164 of 263 (879347)
07-15-2020 3:50 AM
Reply to: Message 163 by Kleinman
07-15-2020 3:35 AM


Re: Self Serving Beliefs
quote:
Now you are so stupid, you think the drug-resistant infections and failed cancer treatments don't occur by evolution.
No, I just don’t believe your accusation that evolutionary scientists are to blame. An accusation made without evidence.
quote:
Oh really? What evidence you moron?
The catalog of evasions and errors that make up your posting history.
quote:
Earlier in our discussion, you said something that made me think you might get what the correction needs to be in the Jukes-Cantor model so that it would correctly predict the Kishony experiment. Go back and think about what you said, watch the YouTube videos that I gave links to that talk about how to do Markov chain computations, study the Wikipedia page on DNA evolution, in other words, do your own homework you silly jerk.
And look another error and another evasion. You want me to tell you how you decided to fix Jukes-Cantor to make it do something it shouldn’t do. Well I don’t know what you decided to do, because I don’t read minds.

This message is a reply to:
 Message 163 by Kleinman, posted 07-15-2020 3:35 AM Kleinman has replied

Replies to this message:
 Message 165 by Kleinman, posted 07-15-2020 1:55 PM PaulK has replied

PaulK
Member
Posts: 17828
Joined: 01-10-2003
Member Rating: 2.3


Message 166 of 263 (879376)
07-15-2020 2:20 PM
Reply to: Message 165 by Kleinman
07-15-2020 1:55 PM


Re: Self Serving Beliefs
More evasion. You can’t describe your model because you don’t have one or know how to build one.

This message is a reply to:
 Message 165 by Kleinman, posted 07-15-2020 1:55 PM Kleinman has replied

Replies to this message:
 Message 167 by Kleinman, posted 07-15-2020 2:56 PM PaulK has replied

PaulK
Member
Posts: 17828
Joined: 01-10-2003
Member Rating: 2.3


Message 168 of 263 (879387)
07-15-2020 3:05 PM
Reply to: Message 167 by Kleinman
07-15-2020 2:56 PM


Re: Self Serving Beliefs
I’ve read those papers. I’m not sure you have. You certainly didn’t read those web pages about the Jukes-Cantor model. Let alone any more authoritative source. Nobody writing a scientific paper relating to that model could be as ignorant of it as you were,
Which is how I know you aren’t writing a paper and don’t have a model.

This message is a reply to:
 Message 167 by Kleinman, posted 07-15-2020 2:56 PM Kleinman has replied

Replies to this message:
 Message 169 by Kleinman, posted 07-15-2020 3:28 PM PaulK has replied

PaulK
Member
Posts: 17828
Joined: 01-10-2003
Member Rating: 2.3


Message 170 of 263 (879392)
07-15-2020 3:43 PM
Reply to: Message 169 by Kleinman
07-15-2020 3:28 PM


Re: Self Serving Beliefs
If you had a model you could talk about it. You could show that I was wrong. But you don’t because I’m right.
(And you really think that a 2 base Jukes-Cantor would be worth worth doing and a 3 base version isn’t? Message 1891. Oh dear, oh dear.)

This message is a reply to:
 Message 169 by Kleinman, posted 07-15-2020 3:28 PM Kleinman has replied

Replies to this message:
 Message 171 by Kleinman, posted 07-15-2020 5:47 PM PaulK has replied

PaulK
Member
Posts: 17828
Joined: 01-10-2003
Member Rating: 2.3


(1)
Message 174 of 263 (879411)
07-16-2020 12:12 AM
Reply to: Message 171 by Kleinman
07-15-2020 5:47 PM


Re: Self Serving Beliefs
quote:
The 3 base version of the non-stationary Jukes-Cantor model and a mutation rate of E-9 will take over 1e26 replications (not generations, you dodo) for each successful evolutionary step (and that is not equilibrium).
Oh, you mean a model which requires three bases to change? In sequence? Well that isn’t very sensible. Not that the two base model would be worth doing either. Of course models of selection aren’t Jukes-Cantor or corrections of Jukes-Cantor - even if you only track one base. I’m sorry for thinking that you might at least have been considering the real problems of modelling the Kishony experiment with a Markov chain.
But there is a very sensible reason why a model that uses selection might want to track three bases and not two.
But you don’t know it because you don’t have a model and aren’t even trying to build one.

This message is a reply to:
 Message 171 by Kleinman, posted 07-15-2020 5:47 PM Kleinman has replied

Replies to this message:
 Message 176 by Kleinman, posted 07-16-2020 9:33 AM PaulK has replied

PaulK
Member
Posts: 17828
Joined: 01-10-2003
Member Rating: 2.3


Message 188 of 263 (879504)
07-17-2020 10:21 AM
Reply to: Message 176 by Kleinman
07-16-2020 9:33 AM


Re: Self Serving Beliefs
quote:
There's no point in discussing my model when the mathematically incompetent PaulK doesn't understand the Jukes-Cantor model and what is simulates physically
Then since I know it well enough to correct your errors on a number of occasions it would follow that you are incapable of creating a corrected version. Not least because you don’t understand what it’s meant to model. So that’s an implicit admission that you have nothing.
As for mathematical incompetence:
quote:
Then go a little further down the page and find the paragraph titled "Deriving the dynamics of substitution" and you will find the vector equation:
E = {A,G,C,T}
When I look at that I don’t see a vector equation I see the set of possible states. Why don’t we look at the next line and see what it is?
be the set of possible states for the site, and

This message is a reply to:
 Message 176 by Kleinman, posted 07-16-2020 9:33 AM Kleinman has replied

Replies to this message:
 Message 190 by Kleinman, posted 07-17-2020 10:53 AM PaulK has replied

PaulK
Member
Posts: 17828
Joined: 01-10-2003
Member Rating: 2.3


Message 191 of 263 (879515)
07-17-2020 11:03 AM
Reply to: Message 190 by Kleinman
07-17-2020 10:53 AM


Re: Self Serving Beliefs
If I was really that dumb you wouldn’t be so scared of posting your alleged model. Or your arguments.
But thank you for providing more evidence that Creationism is just a silly Satan cult.

This message is a reply to:
 Message 190 by Kleinman, posted 07-17-2020 10:53 AM Kleinman has replied

Replies to this message:
 Message 192 by Kleinman, posted 07-17-2020 11:22 AM PaulK has replied

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