That the biggest possible circle ever wouldn't allow us to scientifically measure the pi ratio down to the 50th decimal place...
That biggest possible circle wouldn't allow us to measure pi at all since the circumference/diameter of a circle only equals pi in a flat (Euclidian) space, which our universe isn't on a large scale. For example, on the surface of a sphere the largest possible circle has a C/D = 2. Thus, C/D = pi is a very contingent result, i. e., is true of certain realities and not of others.
On the other hand, even if we had never stumbled on the fact that C/D = pi in the locally flat part of the universe we live in we would have still discovered pi, and been able to calculate it to arbitrary precision in other contexts. For example:
1 - 1/3 + 1/5 - 1/7 + 1/9 - 1/11 + ......... = pi/4.
This is true anywhere in our universe and anywhere in any universe.
...but we can still calculate what it(pi) precisely is shows that not every objective thing can be scientifically investigated.
The precision with which we can calculate (or measure) something has absolutely nothing to do with its ability to be subjected to scientific investigation. Or am I misunderstanding you.