Mutations

As Weinberg in commenting on Wolfram ADMITTED that physicists care less than more for the kinds of squiggly tracks that highlight Feynman lectures and Wolfram did not spell out his own understood difference of field theory and mechanics quantum wise it seems specious to me to inquire how SHAPE changes can be classed into random divisions. How are proximate causes due to photons to be accounted? What if only a change in a degree C mattered?? One has to have an accepted basis of "change". If one intends on imagining differences in genotype and phenotype "randomly" then I see no way sort of definitive knoweldge how to even postulate unambiguously such.