The ultimate tactic will be to attack genetics at core - not scientifically, just through assertion - as they have done with every other killer evidence. Start with C14 dating - killer to the timescale, therefore is isn't reliable and not worth considering (not 'it isn't reliable because we got readings five times younger' - they can't do that because the multiples are so huge they sound silly even saying it).
Next archaelogy - clear evidence of pre-creation civilisations. Killer - ahh that relies on the C14 which we've already shown is unreliable...
No use trying to mutter about styles of pottery or type of furnace or insect, grass&pollen spores and the host of other supporting methods and data used...they only need one point of attack.
So for this argument the problem is that genetic code is wrong. It cannot be right because it doesn't support the Ark therefore by definition it must be wrong.
The interest lies in waiting to see if there is one knowledgable enough to even talk vaguely about genetics without sounding like a fool, and then which line of attack he will try....