evolution calculations

No. Hardy-Weinberg is a theoretical model (with lots of assumptions and limitations) that shows how alleles can become fixed in a population.OTOH, Orr's equations can show how cumulative mutations can result in hybrid incompatibilities leading to speciation that absolutely guarantees evolution happens. Since I have no clue how to post complex equations here, I can only reference the article where he puts forward his theoretical model:H. Allen Orr, 1995, "The Population Genetics of Speciation: The Evolution of Hybrid Incompatibilities", Genetics 139:1805-1813

quote:

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Abstract:

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Speciation often results from the accumulation of complementary genes, ie., from genes that, while having no deleterious effect within species, cause inviability or sterility when brought together with genes from another species. Here I model speciation as the accumulation of genic incompatibilities between diverging populations. Several results are obtained. First, and most important, the number of genic incompatibilities between taxa increases much faster than linearly with time. In particular, the probability of speciation increases at least as fast as the square of the time since separation between two taxa. Second, as Muller realized, all hybrid incompatibilities must initially be asymmetric. Third, at loci that have diverged between taxa, evolutionarily derived alleles cause hybrid problems far more often than ancestral alleles. Last, it is easier to evolve complex hybrid incompatibilities requiring the simultaneous action of three or more loci than to evolve simple incompatibilities between pairs of genes. These results have several important implications for genetic analyses of speciation.

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IOW, speciation has to happen.

You're right, I misspoke. H-W deals with allele frequencies and how they change over time leading to specific ratios (equilibrium). It also shows that a variant can never be lost from a population once it's there. Among others like completely random mating, non-overlapping generations, no mutation, no immigration/emigration, and no natural selection (although you can add a selection coefficient to H-W and get a reasonable result that still fits with the original equations). Right. That's why I'm not a theoretician. I prefer to use models that at least attempt to reflect something like reality. H-W doesn't reflect reality, Orr comes a bit closer but he's dealing with something completely different than the basic pop-gen equations.

That, and the fact that under any of the H-W equations + additional coefficients no allele is ever lost in a population. Ever.

Well, it may or may not be a "fundamental issue". It IS off-topic for this thread. There are a bunch of still-open threads on the board that discuss the information question. You might want to consider reposting this in one of them. You're likely to get better answers to your statements there.Just a thought.