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Author Topic:   Why is evolution so controversial?
Taq
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Posts: 10085
Joined: 03-06-2009
Member Rating: 5.1


Message 586 of 969 (739428)
10-23-2014 6:46 PM
Reply to: Message 585 by zaius137
10-23-2014 5:27 PM


Re: What if God used evolution to create man?
Yes at the time the paper was accepted there was no controversy about mutation rates because indels were not in play, that is because they were not thought to affect protein coding.
Then why do you use 5% in your calculations? If you use 5% then you are saying that all 5% were substitutions.
The real number is 35 million substitutions and 5 million indels between both lineages, or 20 million total mutations per lineage. That is the real number. If you are using 5% of 3 billion, or 150 million mutations, then you are way off.
"Here we present a draft genome sequence of the common chimpanzee (Pan troglodytes). Through comparison with the human genome, we have generated a largely complete catalogue of the genetic differences that have accumulated since the human and chimpanzee species diverged from our common ancestor, constituting approximately thirty-five million single-nucleotide changes, five million insertion/deletion events, and various chromosomal rearrangements."
Initial sequence of the chimpanzee genome and comparison with the human genome | Nature
Edited by Taq, : No reason given.

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 Message 585 by zaius137, posted 10-23-2014 5:27 PM zaius137 has not replied

Replies to this message:
 Message 587 by Dr Jack, posted 10-23-2014 6:50 PM Taq has replied

  
Dr Jack
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Posts: 3514
From: Immigrant in the land of Deutsch
Joined: 07-14-2003
Member Rating: 8.3


Message 587 of 969 (739429)
10-23-2014 6:50 PM
Reply to: Message 586 by Taq
10-23-2014 6:46 PM


Re: What if God used evolution to create man?
It's worth noting at this point that there is no single and coherent definition of what the difference between two sequences is.

This message is a reply to:
 Message 586 by Taq, posted 10-23-2014 6:46 PM Taq has replied

Replies to this message:
 Message 588 by Taq, posted 10-23-2014 6:56 PM Dr Jack has seen this message but not replied
 Message 598 by Genomicus, posted 10-23-2014 8:32 PM Dr Jack has replied

  
Taq
Member
Posts: 10085
Joined: 03-06-2009
Member Rating: 5.1


Message 588 of 969 (739430)
10-23-2014 6:56 PM
Reply to: Message 587 by Dr Jack
10-23-2014 6:50 PM


Re: What if God used evolution to create man?
It's worth noting at this point that there is no single and coherent definition of what the difference between two sequences is.
The standard methods use parsimony as the guiding principle which means that the difference is the fewest mutations needed to to reconstruct the ancestral genome, if my understanding is accurate. The algorithms used for alignment may not be completely standardized, but I have yet to see massive differences between alignment methods that would allow for 5 or 10 fold differences in mutation rates.
In other words, a 4 base gap in an alignment is assumed to be a single indel event of 4 bases in stead of 4 individual indel events. Zaius is treating a 4 base indel as 4 separate mutations. A point mutation is assumed to be a single change in one lineage instead of multiple mutations at the same base. Sequence that can not be aligned with strong confidence is kept out of the comparison.
Edited by Taq, : No reason given.
Edited by Taq, : No reason given.

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New Cat's Eye
Inactive Member


Message 589 of 969 (739431)
10-23-2014 6:58 PM
Reply to: Message 585 by zaius137
10-23-2014 5:27 PM


Re: What if God used evolution to create man?
Yes at the time the paper was accepted there was no controversy about mutation rates
What do you mean by controversy, and what is the point of mentioning it?
Look, whatever the rate of mutation was, is what it was. It doesn't really matter what evidence we had a particular time, nor how confident we are in the changes to our understanding that we've uncovered.
Regardless, you're going to want to use the most appropriate figure possible.
I can do the math.
Yes, but you're using the wrong value for one of the variables. You've misunderstood what the variabe represents and have used the wrong data for it.
I really need a quote (in the literature) from you to back up your point.
Nah, that's setting the bar too high.
Just think about it, which is more likely:
  • You've uncovered a calculation that proves that decades of accepted science has been completely wrong
  • You made a mistake in your calculation
So?
It has already been found that the necessary point mutations to reconcile a chimp human split at 5.6 million years is deficient by about half the needed mutations, since this paper was written.
Calculated: 175 mutations per generation.
Found empirically: 70 mutations.
Obviously that calculation is way off.
Why do you think that is?
If its because you think that humans and chimps didn't evolve from a common ancestor, then from a scientific perspective: how the heck else did they get here?

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 Message 585 by zaius137, posted 10-23-2014 5:27 PM zaius137 has not replied

  
Taq
Member
Posts: 10085
Joined: 03-06-2009
Member Rating: 5.1


Message 590 of 969 (739432)
10-23-2014 7:10 PM
Reply to: Message 554 by zaius137
10-22-2014 7:58 PM


Re: What if God used evolution to create man?
5.6 million years is 244 thousand generations (given 23 years per generation).
t= number of generations since divergence (244 thousand)
k= percentage of sequence divergence Estimated at 5%
Ne= effective size of population ~10^3
(u)= mutation rate needed.
u= k/(2t+4Ne) or 9.5x10^-8 or ~ 600 mutations per generation (mutation rate times the diploid genome in humans).
If you are going to use indels, then you need to treat them as single mutations. 1.33% divergence is correct because 1.33% of 3E[9] is 39.9 million mutations, the total number of substitutions and indels added together.
Also, you only have an effective population size of 1,000. That's way low. Most calculations use a minimum of 10,000, and many have 100,000.
edit: mistakenly had 3E6 for human genome size before.
Edited by Taq, : No reason given.
Edited by Taq, : No reason given.

This message is a reply to:
 Message 554 by zaius137, posted 10-22-2014 7:58 PM zaius137 has replied

Replies to this message:
 Message 592 by zaius137, posted 10-23-2014 7:50 PM Taq has replied

  
zaius137
Member (Idle past 3438 days)
Posts: 407
Joined: 05-08-2012


Message 591 of 969 (739433)
10-23-2014 7:37 PM
Reply to: Message 577 by dwise1
10-23-2014 2:51 PM


Re: PRATT: The Bunny Blunder Strikes Again!
quote:
Read the rest of that page for the complete explanation. You, like Dr. Henry Morris, PhD Hydraulic Engineering, former President of the ICR and co-creator of "creation science", made the fundamental mistake of using an invalid mathematical model. You both used the "pure-birth model", which makes the assumption of unlimited resources so there are no limits placed on population growth. In reality, the environment can only support a limited number of critters (eg, bunnies, humans), so as the population approaches that limit, known as the environment's "carrying capacity", its growth starts to slow down, stop, and even go into fluctuation between periods of growth and decline. The model that takes carrying capacity into account is called the "logistic model" and even that model cannot take into account other significant factors, such as predator-prey cycles and catastrophic events (eg, the Black Death, during which the European population's growth rate declined) and migration (which is a factor when trying to model the growth of the US population).
Silly people Don’t believe everything you read at talkorigins.com
Did you know that (r) the rate of natural increase is a unit less factor that auto adjusts environment, reproductive rates and food source (among other things). The value of accepted (r) is between .01 and .005 for humans. The plague in Europe and the world wars do affect the value of (r). Otherwise humans usually settle in environments conducive to their well being and reproductive benefit.
Now lets look at the bunny
N = ne^rt
Biblical (r) prior to the plague = .007 to .01
I will use post plague and world wars for a value of (r) = .005
About the number of individuals around the year 2500 bc (scratch this, it is prior flood)
If you use (r) = .005 from 4300 years ago and 8 individuals in the ark you get a population of 7 billion
You know what is even sillier 10 thousand humans hanging around for 50,000 years with effective zero population growth. You know that long narrow bottleneck theory that is accepted in evolution dynamics.
using (r) = .005 over 50,000 years with an initial population of 10 thousand you get (OOPs error overflow). My calculator does not display such large numbers.
Now who’s proposition is sillier?
Numbers don’t lie people do
Edited by zaius137, : My error

This message is a reply to:
 Message 577 by dwise1, posted 10-23-2014 2:51 PM dwise1 has replied

Replies to this message:
 Message 594 by Taq, posted 10-23-2014 8:04 PM zaius137 has not replied
 Message 599 by Dr Adequate, posted 10-23-2014 9:19 PM zaius137 has not replied
 Message 601 by dwise1, posted 10-23-2014 11:57 PM zaius137 has replied
 Message 636 by Modulous, posted 10-24-2014 4:34 PM zaius137 has replied

  
zaius137
Member (Idle past 3438 days)
Posts: 407
Joined: 05-08-2012


Message 592 of 969 (739435)
10-23-2014 7:50 PM
Reply to: Message 590 by Taq
10-23-2014 7:10 PM


Re: What if God used evolution to create man?
quote:
If you are going to use indels, then you need to treat them as single mutations. 1.33% divergence is correct because 1.33% of 3E6 is 39.9 million mutations, the total number of substitutions and indels added together.
Also, you only have an effective population size of 1,000. That's way low. Most calculations use a minimum of 10,000, and many have 100,000.
I think that would be 1.33% x ~6.4 billion (remember diploid genome).
Went back in my notes, I did use 10,000, just recorded wrong.

This message is a reply to:
 Message 590 by Taq, posted 10-23-2014 7:10 PM Taq has replied

Replies to this message:
 Message 593 by Taq, posted 10-23-2014 8:02 PM zaius137 has not replied
 Message 595 by Coyote, posted 10-23-2014 8:19 PM zaius137 has not replied

  
Taq
Member
Posts: 10085
Joined: 03-06-2009
Member Rating: 5.1


Message 593 of 969 (739436)
10-23-2014 8:02 PM
Reply to: Message 592 by zaius137
10-23-2014 7:50 PM


Re: What if God used evolution to create man?
I think that would be 1.33% x ~6.4 billion (remember diploid genome).
For the number of mutations you use a haploid genome. You will notice in the chimp genome paper that they list the coverage as more than 90%, and the total number of bases sequenced as 2.7 billion bases.
"The ARACHNE assembly has slightly greater continuity (Table 1) and was used for analysis in this paper. The draft genome assemblygenerated from ~3.6-fold sequence redundancy of the autosomes and ~1.8-fold redundancy of both sex chromosomescovers ~94% of the chimpanzee genome with >98% of the sequence in high-quality bases."
Initial sequence of the chimpanzee genome and comparison with the human genome | Nature
Here is a table showing the total number of bases sequenced:
Initial sequence of the chimpanzee genome and comparison with the human genome | Nature
The 40 million total mutations are referring to a 3 billion base haploid genome.

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 Message 592 by zaius137, posted 10-23-2014 7:50 PM zaius137 has not replied

  
Taq
Member
Posts: 10085
Joined: 03-06-2009
Member Rating: 5.1


Message 594 of 969 (739437)
10-23-2014 8:04 PM
Reply to: Message 591 by zaius137
10-23-2014 7:37 PM


Re: PRATT: The Bunny Blunder Strikes Again!
Silly people Don’t believe everything you read at talkorigins.com
Do you really think that the human population always grew at a set rate? Really? That's a completely unsupported assumption.

This message is a reply to:
 Message 591 by zaius137, posted 10-23-2014 7:37 PM zaius137 has not replied

Replies to this message:
 Message 623 by RAZD, posted 10-24-2014 2:11 PM Taq has not replied

  
Coyote
Member (Idle past 2135 days)
Posts: 6117
Joined: 01-12-2008


(1)
Message 595 of 969 (739438)
10-23-2014 8:19 PM
Reply to: Message 592 by zaius137
10-23-2014 7:50 PM


You're ducking
You still have not answered the question:
What date do you put for the origin of modern humans?
And upon what do you base your answer?

Religious belief does not constitute scientific evidence, nor does it convey scientific knowledge.
Belief gets in the way of learning--Robert A. Heinlein
How can I possibly put a new idea into your heads, if I do not first remove your delusions?--Robert A. Heinlein
It's not what we don't know that hurts, it's what we know that ain't so--Will Rogers
If I am entitled to something, someone else is obliged to pay--Jerry Pournelle
If a religion's teachings are true, then it should have nothing to fear from science...--dwise1
"Multiculturalism" does not include the American culture. That is what it is against.

This message is a reply to:
 Message 592 by zaius137, posted 10-23-2014 7:50 PM zaius137 has not replied

Replies to this message:
 Message 597 by Genomicus, posted 10-23-2014 8:23 PM Coyote has replied

  
Taq
Member
Posts: 10085
Joined: 03-06-2009
Member Rating: 5.1


(1)
Message 596 of 969 (739439)
10-23-2014 8:22 PM


An indel is a single event
Just to make this clearer, here are two made up sequences
AAGTGTTACCGAGTCCATAAATGCCCC
AAGTGTTA_____TCCATAAATGCCCC
There are 27 bases in the top sequence. When we do an alignment with the bottom sequence we see a 5 base gap. This is a 5 base indel. Using parsimony, this would be considered a single 5 base indel event, a single mutation.
However, the sequences only match at 20 of 27 bases. Therefore, they have~ 80% sequence identity at the base level. One mutation produces a 20% difference.
This is why you can't use the difference in bases as a measurement of the number of mutations.
Edited by Taq, : No reason given.
Edited by Taq, : No reason given.

  
Genomicus
Member (Idle past 1970 days)
Posts: 852
Joined: 02-15-2012


Message 597 of 969 (739440)
10-23-2014 8:23 PM
Reply to: Message 595 by Coyote
10-23-2014 8:19 PM


Re: You're ducking
You still have not answered the question:
What date do you put for the origin of modern humans?
And upon what do you base your answer?
I'm not quite sure if it's conducive to the clarity of this discussion to go off on slightly different topics/debating points, instead of focusing on the particular argument that he/she put forward. IMHO.
Edited by Genomicus, : No reason given.

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 Message 595 by Coyote, posted 10-23-2014 8:19 PM Coyote has replied

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Genomicus
Member (Idle past 1970 days)
Posts: 852
Joined: 02-15-2012


Message 598 of 969 (739441)
10-23-2014 8:32 PM
Reply to: Message 587 by Dr Jack
10-23-2014 6:50 PM


Re: What if God used evolution to create man?
It's worth noting at this point that there is no single and coherent definition of what the difference between two sequences is.
I'm a little confused on what you mean by this. The difference between two sequences can be quantified relatively easily as the number of differences in aligned base pairs + indels.

This message is a reply to:
 Message 587 by Dr Jack, posted 10-23-2014 6:50 PM Dr Jack has replied

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Dr Adequate
Member (Idle past 313 days)
Posts: 16113
Joined: 07-20-2006


Message 599 of 969 (739443)
10-23-2014 9:19 PM
Reply to: Message 591 by zaius137
10-23-2014 7:37 PM


Re: PRATT: The Bunny Blunder Strikes Again!
Did you know that (r) the rate of natural increase is a unit less factor that auto adjusts environment, reproductive rates and food source (among other things).
This appears to be gibberish.
The value of accepted (r) is between .01 and .005 for humans.
r is, obviously, not a constant.
Now who’s proposition is sillier?
Well, your apparent belief that r can be taken to be constant is screaming twitching lunacy. That's a 10 on the silly scale.
Numbers don’t lie people do
Sadly, creationists lie about numbers.

This message is a reply to:
 Message 591 by zaius137, posted 10-23-2014 7:37 PM zaius137 has not replied

  
Coyote
Member (Idle past 2135 days)
Posts: 6117
Joined: 01-12-2008


(2)
Message 600 of 969 (739445)
10-23-2014 11:27 PM
Reply to: Message 597 by Genomicus
10-23-2014 8:23 PM


Re: You're ducking
You still have not answered the question:
What date do you put for the origin of modern humans?
And upon what do you base your answer?
I'm not quite sure if it's conducive to the clarity of this discussion to go off on slightly different topics/debating points, instead of focusing on the particular argument that he/she put forward. IMHO.
I disagree.
If the poster will admit to a belief in modern humans coming into existence about 6,000 years ago, then we know that we can dismiss all of his arguments as being based on religion and being diametrically opposed to what science has found. That means we don't need to waste our time posting evidence, as no amount of evidence we post will make any difference.
A date for modern humans about 6,000 years ago means that any and all discussions of the specifics of genetics by this poster will be based on beliefs, with no necessary relation to scientific evidence. Those posts will be apologetics, rather than science.
I think this is an important point to establish. Likewise the poster thinks this is an important point to dodge, lest his whole approach be revealed.

Religious belief does not constitute scientific evidence, nor does it convey scientific knowledge.
Belief gets in the way of learning--Robert A. Heinlein
How can I possibly put a new idea into your heads, if I do not first remove your delusions?--Robert A. Heinlein
It's not what we don't know that hurts, it's what we know that ain't so--Will Rogers
If I am entitled to something, someone else is obliged to pay--Jerry Pournelle
If a religion's teachings are true, then it should have nothing to fear from science...--dwise1
"Multiculturalism" does not include the American culture. That is what it is against.

This message is a reply to:
 Message 597 by Genomicus, posted 10-23-2014 8:23 PM Genomicus has not replied

  
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