Of course, all of science is tentative, so Genomics and Systematics are, at the core of it, tentative sciences. However, their conclusions and predictions are so accurate the vast majority of the time, that we can build genetic infrastructures on top of them.
Genomics is the study of the genome, which is the study of DNA, which, through scientific methods, can give scientists accurate insights into the relatedness of species and individuals.
Systematics is a branch of Genomics that deals specifically with species interrelatedness.