I just wanted to post here because I have been having lunch conversations with a sexologist over the last academic semester and I've learned some interesting things.
First of all, it would appear to be very difficult to know what is "hardwired" with regard to sex. Remember that our main evolutionary advantage is having a big large brain which works things out, so our advantage in some sense is to not be hardwired.
Secondly, the field seems to be coming down on the side of human beings being a sexually sequentially monogomous or "shamed" monogomous species. Shamed monogomous means monogomous with occasional allowance for "lapses" which are punished with "shame". Some of our ape relatives are totally monogomous, others are sequentially monogomous, some are shamed monogomous and others are not monogomous, so it can be difficult to settle this from our nearest relatives. However one must keep in mind that we didn't evolve from an animal like pack wolves, so there isn't really an evolutionary precedant for the male to deposit his sperm left, right and centre.
So scientifically monogomy probably isn't entirely cultural or even mostly cultural. The attitude to lapses could be, but that's another issue.
There's some great books on this stuff ranging from academic monographs to near pop-science level. If anybody wants references just ask.