It seems that the Thou Shall Nots are very well defined. You definitely know if you are violating it. However, the Thou Shalls are in a big old gray area.
If the "Thou Shalls" were well defined, then they would look like nagging. And nobody want's a nagging God.
The "Thou Shalt Nots" are not really all that well defined either. For example, it is often stated as "Thou shalt not commit murder" rather than "Thou shalt not kill". This allows all kinds of equivocation. For example, it allows people to convince themselves that tens of thousands of innocent Iraqis being killed is not murder, but is merely an unfortunate side effect of war.
Sad to say, but experience seems to show that the two primary moral principles are:
Might makes right.
You scratch my back, and I'll scratch yours.