Can any of the permutations of e=mc^2 be 'manipulated' in reality to reproduce a predicted outcome? ?
No, they just represent the way mass and energy are related. It is itself a prediction of Einstein's theory of relativity. The prediction is that mass and energy will be related in the fashion described by the equation.
I don't understand your answer.
e can be predicted by one permutation, m by another so why not?