Not unless you think every policy the Federal government fails to carry out is good reason for Sakatchewan to secede.
Yes, I think failures on the part of the federal government would be valid reasons for provinces to consider separation. That's been happening in Quebec for decades with two referendums. Any time you're a member of a group it's healthy to think about why you might want to get out.
... given that those who wanted to leave the EU are also those who most wanted the Commission's plans for refugees to fail....
Is that a given? I know that the people who voted for exit are being branded as racists but I'm not buying it.
The time to get out would be the time at which it appears that the European Commission succeeded in every one of it's proposals, because this would mean we were actually in the situation Euroskeptics complained about - the dictatorial central power which could act without regard for the interests of the member states.
That's what seems like an odd attitude to me. I would want to get out when I found out that there was a dictatorial attitude, not after waiting to see if they were any good at it.